« Previous
Current Problems in Cancer
Volume 34, Issue 2
, Pages 131-149
, March 2010
Current Problems with Systemic Treatment of Advanced Hepatocellular Cancer
References
- . Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology. 2007;132(7):2557–2576
- . Hepatocellular carcinoma incidence, mortality, and survival trends in the United States from 1975 to 2005. J Clin Oncol. 2009;27(9):1485–1491
- http://www.cancer.org/docroot/stt/stt_0.asp
- Improving survival results after resection of hepatocellular carcinoma: a prospective study of 377 patients over 10 years. Ann Surg. 2001;234(1):63–70
- Early hepatocellular carcinoma as an entity with a high rate of surgical cure. Hepatoly. 1998;28(5):1241–1246
- Treatment of hepatocellular carcinoma associated with cirrhosis in the era of liver transplantation. Ann Intern Med. 1998;129(8):643–653
- . Hepatic tumors and cysts. In: Feldman M, Sleisenger M, Scharschmidt B, Klein S editor. ed 6. Sleisenger and Fordtran's Gastrointestinal and Liver Disease: Pathology/Diagnosis/Management. vol 1:Philadelphia, PA: WB Saunders; 1998;p. 1364–1387
- . Digestive diseases in the United States: epidemiology and impact. 1994;NIH publication no. 94-1447
- Randomized phase III trial of sorafenib versus placebo in patients with advanced hepatocellular carcinoma (HCC). Proc Am Soc Clin Oncol. 2007;25(Suppl):18S
- . Hepatocellular carcinoma pathogenesis: from genes to environment. Nat Rev Cancer. 2006;6(9):674–687
- Genetic and epigenetic control of molecular alterations in hepatocellular carcinoma. Exp Biol Med Maywood. 2009;234(7):726–736
- . Hunting for tumor suppressor genes in liver cancer. J Hepatol. 2003;37(4):739–741
- Focus on hepatocellular carcinoma. Cancer Cell. 2004;5(3):215–219
- Genomics and signaling pathways in hepatocellular carcinoma. Semin Liver Dis. 2007;27(1):55–76
- . Hepatitis B virus induced hepatocellular carcinoma. Cancer Lett. 2009;286(1):52–59
- . Pathogenesis of HCV-associated HCC: dual-pass carcinogenesis through activation of oxidative stress and intracellular signaling. Hepatol Res. 2007;37(Suppl 2):S115–S120
- Expression of transforming growth factor-alpha mRNA in livers of patients with chronic viral hepatitis and hepatocellular carcinoma. Cancer. 2000;89(5):977–982
- . Mechanisms of human hepatocarcinogenesis. Curr Mol Med. 2003;3(6):573–588
- Multiple anticancer effects of blocking MEK-ERK signaling in hepatocellular carcinoma. J Am Coll Surg. 2004;198(3):410–421
- Evaluation of extracellular signal regulated kinase expression and its relation to treatment of hepatocellular carcinoma. J Am Coll Surg. 2005;201(3):405–411
- Gefitinib, an EGFR inhibitor, prevents hepatocellular carcinoma development in the rat liver with cirrhosis. Hepatoly. 2005;41(2):307–314
- An evaluation of the role of insulin-like growth factors (IGF) and of type-I IGF receptor signalling in hepatocarcinogenesis and in the resistance of hepatocarcinoma cells against drug-induced apoptosis. Biochem Pharmacol. 2004;68(6):1003–1015
- . Raf kinase as a target for anticancer therapeutics. Mol Cancer Ther. 2005;4(4):677–685
- . Transforming growth factor-alpha and epidermal growth factor receptor in chronic liver disease and hepatocellular carcinoma. Liver. 1999;19(4):318–325
- . Expression of hepatocyte growth factor (HGF) and HGF receptor (c-met) proteins in liver diseases: an immunohistochemical study. Liver. 1999;19(2):151–159
- Expression of vascular endothelial growth factor in human hepatocellular carcinoma. Hepatoly. 1998;28(1):68–77
- Ubiquitous activation of Ras and Jak/STAT pathways in human HCC. Gastroenterology. 2006;130(4):1117–1128
- A multi-institutional phase II study of the efficacy and tolerability of lapatinib in patients with advanced hepatocellular carcinomas. Clin Cancer Res. 2009;15(18):5895–5901
- . Genetics of hepatocellular tumors. Oncogene. 2006;25(27):3778–3786
- Mutations of the BRAF gene in cholangiocarcinoma but not in hepatocellular carcinoma. Gut. 2003;52(5):706–712
- Activation of the ERK and AKT signalling pathway predicts poor prognosis in hepatocellular carcinoma and ERK activation in cancer tissue is associated with hepatitis C virus infection. J Hepatol. 2008;48(1):83–90
- Sustained activation of the Raf/MEK/erk pathway in response to EGF in stable cell lines expressing the hepatitis C virus (HCV) core protein. Oncogene. 2001;20(20):2606–2610
- . Kinase inhibition with bay 43-9006 in renal cell carcinoma. Clin Cancer Res. 2004;10(18 Pt 2):6388S–6392S
- Bay 43-9006 exhibits broad spectrum oral antitumor activity and targets the ref/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004;64(19):7099–7109
- Focal gains of VEGFA and molecular classification of hepatocellular carcinoma. Cancer Res. 2008;68(16):6779–6788
- Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: a phase III randomised, double-blind, placebo-controlled trial. Lancet Oncol. 2009;10(1):25–34
- Final results of phase II, randomized, double-blind study of sorafenib plus doxorubicin and placebo plus doxorubicin in patients with advanced hepatocellular carcinoma. Eur J Cancer. 2007;5(4):Abstract 3500
- Phase II study of erlotinib (OSI-774) in patients with advanced hepatocellular cancer. J Clin Oncol. 2005;23(27):6657–6663
- Gefitinib in advanced unresectable hepatocellular carcinoma: results from the Eastern Cooperatvie Oncology Group's study E1203. J Clin Oncol. 2006;24:4143
- Phase 2 study of cetuximab in patients with advanced hepatocellular carcinoma. Cancer. 2007;110(3):581–589
- A phase II open-label study of cetuximab in unresectable hepatocellular carcinoma: final results. J Clin Oncol. 2007;25:Abstract 4598
- A phase II study of AZD6244 in advanced or metastatic hepatocellular carcinoma. J Clin Oncol. 2009;27(Suppl):Abstract e15574
- Gemcitabine, oxaliplatin (GEMOX) and cetuximab for treatment of hepatocellular carcinoma (HCC): results of the phase II study ERGO. J Clin Oncol. 2007;25(18S):Abstract 4594
- Phase II study of oxliplatin, capecitabine, and cetuximab in advanced hepatocellular carcinoma. J Clin Oncol. 2008;26(suppl):Abstract 4604
- Phase 2 study of erlotinib in patients with unresectable hepatocellular carcinoma. Cancer. 2007;110(5):1059–1067
- Phase II study of efficacy of bevacizumab and erlotinib in inoperable previously untreated hepatocellular carcinoma (HCC). J Clin Oncol. 2009;27(suppl):Abstract e15557
- Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas. Oncogene. 2002;21(31):4863–4871
- . The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell. 2001;105(3):391–402
- Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatoly. 2004;39(6):1683–1693
- Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell. 2005;19(2):159–170
- Hepatitis C virus core protein stimulates hepatocyte growth: correlation with upregulation of wnt-1 expression. Hepatoly. 2005;41(5):1096–1105
- Mutations of beta-catenin and axing I genes are a late event in human hepatocellular carcinogenesis. Liver Int. 2005;25(1):70–76
- Hypermethylation of multiple genes as clonal markers in multicentric hepatocellular carcinoma. Br J Cancer. 2007;97(9):1260–1265
- Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. Clin Cancer Res. 2006;12(18):5369–5376
- Allelotype analysis of hepatocellular carcinoma. Int J Cancer. 1998;75(1):29–33
- Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology. 2001;120(7):1763–1773
- Pivotal role of mTOR signaling in hepatocellular carcinoma. Gastroenterology. 2008;135:1972–1983
- Activation of Akt-mTOR-p70s6k pathway in angiogenesis in hepatocellular carcinoma. Oncol Rep. 2008;20(4):713–719
- MTOR, a novel target in breast cancer: the effect of CCI-779, an mTOR inhibitor, in preclinical models of breast cancer. Endocr Relat Cancer. 2001;8(3):249–258
- PTEN/MMAC1 mutation and frequent loss of heterozygosity identified in chromosome 10q in a subset of hepatocellular carcinomas. Jpn J Cancer Res. 2000;91(3):287–292
- Transcriptome classification of HCC is related to gene alterations and to new therapeutic targets. J Hepatol. 2007;45(1):42–52
- Rapamycin and CCI-779 inhibit the mammalian target of rapamycin signalling in hepatocellular carcinoma. Liver Int. 2009;30(1):65–75
- Ras pathway activation in hepatocellular carcinoma and anti-tumoral effect of combined sorafenib and rapamycin in vivo. J Hepatol. 2009;51(4):725–733
- Randomized, phase I, and pharmacokinetic (PK) study of RAD001, an mTOR inhibitor, in patients(pts) with advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2009;27(Suppl):Abstract 4587
- Pilot study of sirolimus in cirrhotic patients with advanced hepatocellular carcinoma. 2009 Gastrointestinal Cancers Symposium. 2009;
- Daily dose of perifosine less toxic than weekly and active in patients with hepatocellular carcinoma (HCC). J Clin Oncol. 2007;25(18S):15072
- . Dysregulation of growth factor signaling in human hepatocellular carcinoma. Oncogene. 2006;25(27):3787–3800
- Pathogenesis of hepatocellular carcinoma and molecular therapies. Curr Opin Gastroenterol. 2009;25(3):186–194
- Loss of heterozygosity of the mannose 6-phosphate/insulin-like growth factor II receptor and p53 genes in human hepatocellular carcinoma. Hepatol Res. 2001;20(1):68–83
- . Insulin-like growth factor 1 receptor targeted therapeutics: novel compounds and novel treatment strategies for cancer medicine. Recent Pat Anticancer Drugs Discov. 2009;4(1):54–72
- IMC-A12, a human IgG1 monoclonal antibody to the insulin-like growth factor I receptor. Clin Cancer Res. 2007;13(18 Pt 2):5549s–5555s
- . Growth factor-regulated G1 cyclins. Stem Cells. 1994;12(Suppl 1):47–55discussion 55-7
- . Cell cycle control as a basis for cancer drug development (review). Int J Oncol. 2000;16(5):871–886
- Selective G to T mutations of p53 gene in hepatocellular carcinoma from southern Africa. Nature. 1991;350(6317):429–431
- p53 gene mutation and integrated hepatitis B viral DNA sequences in human liver cancer cell lines. Carcinogenesis. 1993;14(5):987–992
- Hepatitis B x antigen and p53 are associated in vitro and in liver tissues from patients with primary hepatocellular carcinoma. Oncogene. 1993;8(5):1109–1117
- Alterations of tumor suppressor genes and allelic losses in human hepatocellular carcinomas in China. Cancer Res. 1994;54(1):281–285
- . Genetic alterations associated with hepatocellular carcinoma. Gastroenterol Clin Biol. 1997;21(1):34–44
- Comprehensive allelotyping of human hepatocellular carcinoma. Oncogene. 1997;14(24):2927–2933
- CDK inhibitors: from the bench to clinical trials. Curr Drug Targets. 2009;Epub ahead of print
- Examination of oncogene amplification by genomic DNA microarray in hepatocellular carcinomas: comparison with comparative genomic hybridization analysis. Cancer Genet Cytogenet. 2001;130(2):127–132
- Bevacizumab in unresectable hepatocellular carcinoma (HCC) for patients without metastasis and without invasion of the portal vein. J Clin Oncol. 2006;24(Suppl):4144
- Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring. J Clin Oncol. 2007;25(18S):Abstract 4570
- Efficacy and tolerability of bevacizumab plus capecitabine as first-line therapy in patients with advanced hepatocellular carcinoma. Br J Cancer. 2010;102:981–986
- Combination of capecitabine, oxaliplatin with bevacizumab in treatment of advanced hepatocellular carcinoma (HCC): a phase II study. J Clin Oncol. 2007;25(18S):Abstract 4574
- Sun11248 inhibits KIT and platelet-derived growth factor receptor beta in preclinical models of human small cell lung cancer. Mol Cancer Ther. 2003;2(5):471–478
- A phase II study of sunitinib in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2007;25(18S):Abstract 4637
- Assessment of safety and drug-induced tumor necrosis with sunitinib in patients (pts) with unresectable hepatocellular carcinoma (HCC). J Clin Oncol. 2007;25:149s
- Phase II study of sunitinib malate in adult patients with metastatic or surgically unresectable hepatocellular carcinoma (HCC). In: 2008 Gastrointestinal Cancer Symposium Abstract 267. Orlando, FL: American Society of Oncology; 25-27 January 2008;p. 202
- Continuous sunitinib treatment in patients with unresectable hepatocellular carcinoma (HCC): A multicenter phase II trail (SAKK77/06 and SASL 23). J Clin Oncol. 2009;27(Suppl):Abstract 4591
- . Preclinical and clinical development of the oral multikinase inhibitor sorafenib in cancer treatment. Drugs Today. 2005;41(12):773–784
- Sorafenib in advanced hepatocellular carcinoma. N Engl J Med. 2008;359(4):378–390
- A phase II study of sorafenib in combination with tegafur/uracil (UFT) for Asian patients with advanced hepatocellular carcinoma (HCC). J Clin Oncol. 2009;27(Suppl):Abstract 4589
- A phase II (PhII) trial of sorafenib (S) in combination with 5-fluorouracil (5FU) continuous infusion (c.i.) in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary data. J Clin Oncol. 2009;27(Suppl):Abstract 4592
- Phase II trial evaluating the clinical and biologic effects of bevacizumab in unresectable hepatocellular carcinoma. J Clin Oncol. 2008;26(18):2992–2998
- Bevacizumab in patients (pts) with advanced hepatocellular carcinoma (HCC): preliminary results of a phase II study with circulating endothelial cell (CEC) monitoring. J Clin Oncol. 2007;25(suppl):Abstract 4570
- Phase II study of gemcitabine and oxaliplatin in combination with bevacizumab in patients with advanced hepatocellular carcinoma. J Clin Oncol. 2006;24(12):1898–1903
- Phase II trial of the combination of bevacizumab and erlotinib in patients who have advanced hepatocellular carcinoma. J Clin Oncol. 2009;27(6):843–850
- A phase II study of lapatinib in patients with advanced biliary tree and hepatocellular cancer. Cancer Chemother Pharmacol. 2009;64(4):777–783
- An open-label phase II study of first- and second-line treatment with brivanib in patients with hepatcellular carcinoma (HCC). J Clin Oncol. 2009;27(Suppl):Abstract 4577
- Phase II, open lable study of brivanib alaninate in patients with hepatocellular carcinoma (HCC) who failed prior antiangiogenic therapy. In: 2009 Gastroinestinal Cancers Symposium Abstract 200. Orlando, FL: American Society of Oncology; 25-27, January 2009;p. 202
PII: S0147-0272(10)00022-X
doi: 10.1016/j.currproblcancer.2010.03.001
© 2010 Elsevier Inc. All rights reserved.
« Previous
Current Problems in Cancer
Volume 34, Issue 2
, Pages 131-149
, March 2010
