Current Problems in Cancer
Volume 33, Issue 3 , Pages 125-141 , May 2009

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal Surface Malignancy: Overview and Rationale

  • Perry Shen, MD, FACS

      Affiliations

    • Associate Professor of Surgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina
  • ,
  • John H. Stewart IV, MD, FACS

      Affiliations

    • Assistant Professor of Surgery, Director of the Tumor Immunotherapy Program, Wake Forest University School of Medicine, Winston-Salem, North Carolina
  • ,
  • Edward A. Levine, MD, FACS

      Affiliations

    • Professor of Surgery, Chief of Surgical Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina

References 

  1. Pilati P, Rossi CR, Mocellin S, Foletto M, Scagnet B, Pasetto L, et al. Multimodal treatment of peritoneal carcinomatosis and sarcomatosis. Eur J Surg Oncol. 2001;27:125–134
  2. Sadeghi B, Arvieux C, Glehen O, Beaujard AC, Rivoire M, Baulieux J, et al. Peritoneal carcinomatosis from non-gynecologic malignancies: Results of the EVOCAPE 1 multicentric prospective study. Cancer. 2000;88:358–363
  3. Sugarbaker PH. Peritonectomy procedures. Ann Surg. 1995;221:29–42
  4. Torisu M, Katano M, Kimura Y, Itoh H, Takesue M. New approach to management of malignant ascites with a streptococcal preparation OK 432: Improvement of host immunity and prolongation of survival. Surgery. 1983;93:357-3
  5. Spratt J, Adcock M, Muskovin M, Sherrill W. Clinical delivery system for intraperitoneal hyperthermic chemotherapy. Cancer Res. 1980;40:256–260
  6. Shen P, Levine EA, Hall J, Case D, Russell G, Fleming R. Factors predicting survival after intraperitoneal hyperthermic chemotherapy with mitomycin C after cytoreductive surgery for patients with peritoneal carcinomatosis. Arch Surg. 2003;138:26–33
  7. Schwartz PE, Rutherford TJ, Chambers JT, Thiel El, Kohorn RP. Neoadjuvant chemotherapy for advanced ovarian cancer: Long-term survival. Gynecol Oncol. 1999;72:93–99
  8. Levine EA, Stewart JH, Russell GB, Geisinger KR, Loggie BL, Shen P. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: Experience with 501 procedures. J Am Coll Surg. 2007;204:943–953
  9. Sugarbaker PH. Peritoneal Carcinomatosis: Principles and Management. Boston, MA: Kluwer Academic. 1996;337–357
  10. Simpson-Herren L, Sanford L, Holmquist JP. Effects of surgery on the cell kinetics of residual tumor. Cancer Treat Rep. 1976;60:1749–1760
  11. Gundaz N, Fisher B, Saffer EA. Effects of surgical removal on the growth and kinetics of residual tumor. Cancer Res. 1979;39:3661–3865
  12. Los G. Penetration of carboplatin and cisplatin into rat peritoneal tumor nodules after intraperitoneal chemotherapy. Cancer Chemother Pharmacol. 1991;28:159–165
  13. Markman M. Intraperitoneal therapy in ovarian cancer utilizing agents achieving high local but low systemic exposures. Reg Cancer Treat. 1991;3:264–268
  14. Esquivel J, Vidal-Jove J, Steves MA, Sugarbaker PH. Morbidity and mortality of cytoreductive surgery and intraperitoneal chemotherapy. Surgery. 1993;113:631–636
  15. Sugarbaker PH, Zhu BW, Sese GB, Shmookler B. Peritoneal carcinomatosis from appendiceal cancer: Results in 69 patients treated by cytoreductive surgery and intraperitoneal chemotherapy. Dis Colon Rectum. 1993;36:323–329
  16. Jacquet P, Sugarbaker P. Abdominal adhesions causing intestinal obstruction following cytoreduction surgery and early postoperative intraperitoneal chemotherapy. Acta Chir Austriaca. 1995;27:92–95
  17. Jacquet P, Sugarbaker P. Influence of wound healing on gastrointestinal cancer recurrence. Wounds. 1995;7:1–8
  18. Liakakos T, Thomakos N, Fine PM, Dervenis C, Young RL. Peritoneal adhesions: Etiology, pathophysiology, and clinical significance (Recent advances in prevention and management). Digest Surg. 2001;18:260–273
  19. Raftery AT. Regeneration of peritoneum: A fibrinolytic study. J Anat. 1979;129:659–664
  20. Markman M, Cleary S, Howell SB, Lucas WE. Complications of extensive adhesion formation after intraperitoneal chemotherapy. Surg Gynecol Obstet. 1986;162:445–448
  21. Topuz E, Saip P, Aydiner A, Salihoglu Y, Aydin Y, Topuzlu C. Catheter complications associated with intraperitoneal chemotherapy. Eur J Gynaecol Oncol. 1998;19:275–279
  22. Kodera Y, Yamamura Y, Shimizu Y, Torii A, Hirai T, Yasui K, et al. Peritoneal washing cytology: Prognostic value of positive findings in patients with gastric carcinoma undergoing a potentially curative resection. J Surg Oncol. 1999;72:60–64
  23. Basha G, Ghirardi M, Geboes K, Yap SH, Penninckx F. Limitations of peritoneal lavage with antiseptics in prevention of recurrent colorectal cancer caused by tumor-cell seeding: Experimental study in rats. Dis Colon Rectum. 2000;43:1713–1718
  24. Sweitzer KL, Nathanson SD, Nelson LT, Zachary C. Irrigation does not dislodge or destroy tumor cells adherent to the tumor bed. J Surg Oncol. 1993;53:184–190
  25. Giovanella BC, Stehlin JS, Morgan AC. Selective lethal effect of supranormal temperature on human neoplastic cells. Cancer Res. 1976;36:3944–3950
  26. Dudar TE, Jain RK. Differential response of normal and tumor microcirculation to hyperthermia. Cancer Res. 1974;44:605–612
  27. Watanabe M, Tanaka R, Hondo H, Kuroki M. Effects of antineoplastic agents and hyperthermia on cytotoxicity toward chronically hypoxic glioma cells. Int J Hyperthermia. 1992;8:131–138
  28. Teicher BA, Kowal CD, Kennedy KA, Sartorelli AC. Enhancement by hyperthermia of the in vitro cytotoxicity of mitomycin C toward hypoxic tumor cells. Cancer Res. 1981;41:1096–1099
  29. Dawson LE, Russell AH, Tong D, Wisbeck WM. Adenocarcinoma of the sigmoid colon: Sites of initial dissemination and clinical patterns of recurrence following surgery alone. J Surg Oncol. 1983;22:95–99
  30. Russell AH, Tong D, Dawson LE, Wisbeck WM, Griffin TW, Laramore GE, et al. Adenocarcinoma of the retroperitoneal ascending and descending colon: Sites of initial dissemination and clinical patterns of recurrence following surgery alone. Int J Radiat Oncol Biol Phys. 1983;9:361–365
  31. Sugarbaker PH, Yonemura Y. Clinical pathway for the management of resectable gastric cancer with peritoneal seeding: Best palliation with a ray of hope for cure. Oncology. 2000;58:96–107
  32. Deraco M, Raspagliesi F, Kusamura S. Management of peritoneal surface component of ovarian cancer. Surg Oncol Clin North Am. 2003;12:561–583
  33. McQuellon RP, Loggie BW, Fleming RA, Russell GB, Lehman AB, Rambo TD. Quality of life after intraperitoneal hyperthermic chemotherapy (IPHC) for peritoneal carcinomatosis. Eur J Surg Oncol. 2001;27:65–73
  34. McGuire WP, Hoskins WJ, Brady MF, Kucera PR, Partridge EE, Look KY, et al. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatin in patients with stage III and stage IV ovarian cancer. N Engl J Med. 1996;334:1–6
  35. Moertel CG. Peritoneal mesothelioma. Gastroenterology. 1972;63:346–350
  36. Chan PS, Balfour TW, Bourke JB, Smith PG. Peritoneal mesothelioma. Br J Surg. 1975;62:576–580
  37. Brenner J, Sordillo PP, Magill GB, Golbey RB. Malignant peritoneal mesothelioma: Review of 25 patients. Am J Gastroenterol. 1981;75:311–313
  38. Antman KH, Osteen RT, Klegar KL, Amato DA, Pomfret EA, Larson DA, et al. Early peritoneal mesothelioma: A treatable malignancy. Lancet. 1985;2:977–981
  39. de Bree E, Koops W, Kroger R, van Ruth S, Witkamp AJ, Zoetmulder FA. Peritoneal carcinomatosis from colorectal or appendiceal origin: Correlation of preoperative CT with intraoperative findings and evaluation of interobserver agreement. J Surg Oncol. 2004;86:64–73
  40. Low RN, Barone RM, Lacey C, Sigeti JS, Alzate GD, Sebrechts CP. Peritoneal tumor: MR imaging with dilute oral barium and intravenous gadolinium-containing contrast agents compared with unenhanced MR imaging and CT. Radiology. 1997;204:513–520
  41. Sobhani I, Tiret E, Lebtahi R, Aparicio T, Itti E, Montravers F, et al. Early detection of recurrence by 18FDG-PET in the follow-up of patients with colorectal cancer. Br J Cancer. 2008;98:875–880
  42. Iwamoto A, Takahashi T, Sasabe T, Itoh M, Kondoh S, Seiki K, et al. Intraoperative chemotherapy with intraperitoneal activated carbon particles adsorbing mitomycin C against peritoneal dissemination of gastric cancer. Gan To Kagaku Ryoho. 1989;16:2748–2751
  43. Fujimoto S, Takahashi M, Mutou T, Kobayashi K, Toyosawa T, Isawa E, et al. Improved mortality rate of gastric carcinoma patients with peritoneal carcinomatosis treated with intraperitoneal hyperthermic chemoperfusion combined with surgery. Cancer. 1997;79:884–891
  44. Ouchi K, Sugawara T, Ono H, Fujiya T, Kamiyama Y, Kakugawa Y, et al. Therapeutic significance of palliative operations for gastric cancer for survival and quality of life. J Surg Oncol. 1998;69:41–44
  45. Hagiwara A, Togawa T, Yamasaki J, Ohgaki M, Imanishi T, Shirasu M, et al. Extensive gastrectomy and carbon-adsorbed mitomycin C for gastric cancer with peritoneal metastases (Case reports of survivors and their implications). Hepatogastroenterology. 1999;46:1673–1677
  46. Ronnett BM, Zahn CM, Kurman RJ, Kass ME, Sugarbaker PH, Shmookler BM. Disseminated peritoneal adenomucinosis and peritoneal mucinous carcinomatosis (A clinicopathologic analysis of 109 cases with emphasis on distinguishing pathologic features, site of origin, prognosis, and relationship to “pseudomyxoma peritonei.”). Am J Surg Pathol. 1995;19:1390–1408
  47. Gilly FN, Carry PY, Sayag AC, Brachet A, Panteix G, Salle B, et al. Regional chemotherapy (with mitomycin C) and intra-operative hyperthermia for digestive cancers with peritoneal carcinomatosis. Hepatogastroenterology. 1994;41:124–129
  48. Beaujard AC, Glehen O, Caillot JL, Francois Y, Bienvenu J, Panteix G, et al. Intraperitoneal chemohyperthermia with mitomycin C for digestive tract cancer patients with peritoneal carcinomatosis. Cancer. 2000;88:2512–2519
  49. Rey Y, Porcheron J, Talabard JN, Szafnicki K, Balique JG. Peritoneal carcinomatosis treated by cytoreductive surgery and intraperitoneal chemohyperthermia. Ann Chir. 2000;125:631–642
  50. Sugarbaker PH, Chang D. Results of treatment of 385 patients with peritoneal surface spread of appendiceal malignancy. Ann Surg Oncol. 1999;6:727–731
  51. Look M, Chang D, Sugarbaker PH. Long-term results of cytoreductive surgery for advanced and recurrent epithelial ovarian cancers and papillary serous carcinoma of the peritoneum. Int J Gynecol Cancer. 2004;14:35–41
  52. Sebbag G, Yan H, Shmookler BM, Chang D, Sugarbaker PH. Results of treatment of 33 patients with peritoneal mesothelioma. Br J Surg. 2000;87:1587–1593
  53. Kubik-Huch RA, Dörffler W, von Schulthess GK, Marincek B, Köchli OR, Seifert B, et al. Value of (18F)-FDG positron emission tomography, computed tomography, and magnetic resonance imaging in diagnosing primary and recurrent ovarian carcinoma. Eur Radiol. 2000;10:761–767
  54. Tentes AA, Tripsiannis G, Markakidis SK, Karanikiotis CN, Tzegas G, Georgiadis G, et al. Peritoneal cancer index: A prognostic indicator of survival in advanced ovarian cancer. Eur J Surg Oncol. 2003;29:69–73
  55. Berthet B, Sugarbaker TA, Chang D, Sugarbaker PH. Quantitative methodologies for selection of patients with recurrent abdominopelvic sarcoma for treatment. Eur J Cancer. 1999;35:413–419
  56. Sebbag G, Sugarbaker PH. Peritoneal mesothelioma proposal for a staging system. Eur J Surg Oncol. 2001;27:223–224
  57. Shen P, Hawksworth J, Lovato J, Loggie BW, Geisinger KR, Fleming RA, et al. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy with mitomycin C for peritoneal carcinomatosis from nonappendiceal colorectal carcinoma. Ann Surg Oncol. 2004;11:178–186
  58. Stewart JH, Shen P, Russell GB, Bradley RF, Hundley JC, Loggie BL, et al. Appendiceal neoplasms with peritoneal dissemination: Outcomes after cytoreductive surgery and intraperitoneal hyperthermic chemotherapy. Ann Surg Oncol. 2006;13:624–634
  59. Levine EA, Stewart JH, Russell GB, Geisinger KR, Loggie BL, Shen P. Cytoreductive surgery and intraperitoneal hyperthermic chemotherapy for peritoneal surface malignancy: Experience with 501 procedures. J Am Coll Surg. 2007;204:943–953
  60. Glehen O, Kwiatkowski F, Sugarbaker PH, Elias D, Levine EA, De Simone M, et al. Cytoreductive surgery combined with perioperative intraperitoneal chemotherapy for the management of peritoneal carcinomatosis from colorectal cancer: A multi-institutional study. J Clin Oncol. 2004;22:3284–3292
  61. Glehen O, Cotte E, Kusamura S, Deraco M, Baratti D, Passot G, et al. Hyperthermic intraperitoneal chemotherapy: Nomenclature and modalities of perfusion. J Surg Oncol. 2008;98:242–246
  62. Ahmad SA, Kim J, Sussman JJ, Soldano DA, Pennington LJ, James LE, et al. Reduced morbidity following cytoreductive surgery and intraperitoneal hyperthermic chemoperfusion. Ann Surg Oncol. 2004;11:387–392
  63. Stephens AD, Alderman R, Chang D, Edwards GD, Esquivel J, Sebbag G, et al. Morbidity and mortality analysis of 200 treatments with cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy using the coliseum technique. Ann Surg Oncol. 1999;6:790–796

PII: S0147-0272(09)00026-9

doi: 10.1016/j.currproblcancer.2009.06.003

Current Problems in Cancer
Volume 33, Issue 3 , Pages 125-141 , May 2009