Current Problems in Cancer
Volume 31, Issue 3 , Pages 134-156 , May 2007

Disparities in Breast Cancer

  • Lisa A. Newman, MD, MPH, FACS

      Affiliations

    • Corresponding Author InformationAddress correspondence to Lisa Newman, University of Michigan, Department of Surgery, 3308 Cancer Center, 1500 E Medical Center Drive, Ann Arbor, MI 48109-0932, USA.
  • ,
  • Iman Kalifa Martin, MPH

References 

  1. SEER 2001 Expansion, 2001.
  2. Barnholtz-Sloan JS, de Andrade M, Dyer TD, Chakraborty R. Admixture effects in the traditional linkage analysis of admixed families. Ethn Dis. 2002;12:411–419
  3. Barnholtz-Sloan JS, de Andrade M, Chakraborty R. The impact of population admixture on traditional linkage analysis. Ethn Dis. 2001;11:519–531
  4. Shriver MD, Parra EJ, Dios S, Bonilla C, Norton H, Jovel C, et al. Skin pigmentation, biogeographical ancestry and admixture mapping. Hum Genet. 2003;112:387–399
  5. Smith MW, Lautenberger JA, Shin HD, Chretien JP, Shrestha S, Gilbert DA, et al. Markers for mapping by admixture linkage disequilibrium in African American and Hispanic populations. Am J Hum Genet. 2001;69:1080–1094
  6. SEER Incidence Age-Adjusted Rates, 11 Registries, 1992-99, 2003.
  7. Globocan 2000: Cancer Incidence, Mortality and Prevalence Worldwide (Version 1.0). Lyon: IARC Press; 2001;
  8. Hortobagyi GN, de la Garza Salazar J, Pritchard K, Amadori D, Haidinger R, Hudis CA, et al. The global breast cancer burden: variations in epidemiology and survival. Clin Breast Cancer. 2005;6:391–401
  9. Health Insurance Coverage: 2001. U.S. Census Bureau; 2001;
  10. Proctor B. Current Population Reports: Poverty in the United States: 2001. Washington DC: U.S. Government Printing Office; 2002;
  11. Ward E, Jemal A, Cokkinides V, Singh GK, Cardinez C, Ghafoor A, et al. Cancer disparities by race/ethnicity and socioeconomic status. CA Cancer J Clin. 2004;54:78–93
  12. Lucas FL, Stukel TA, Morris AM, Siewers AE, Birkmeyer JD. Race and surgical mortality in the United States. Ann Surg. 2006;243:281–286
  13. Field TS, Buist DS, Doubeni C, Enger S, Fouayzi H, Hart G, et al. Disparities and survival among breast cancer patients. J Natl Cancer Inst Monogr. 2005;88–95
  14. Weinick RM, Zuvekas SH, Cohen JW. Racial and ethnic differences in access to and use of health care services, 1977 to 1996. Med Care Res Rev. 2000;57(suppl 1):36–54
  15. Fiscella K, Franks P, Doescher MP, Saver BG. Disparities in health care by race, ethnicity, and language among the insured: findings from a national sample. Med Care. 2002;40:52–59
  16. Makuc DM, Breen N, Freid V. Low income, race, and the use of mammography. Health Serv Res. 1999;34:229–239
  17. Haas JS, Phillips KA, Sonneborn D, McCulloch CE, Liang SY. Effect of managed care insurance on the use of preventive care for specific ethnic groups in the United States. Med Care. 2002;40:743–751
  18. Li CI, Malone KE, Daling JR. Differences in breast cancer hormone receptor status and histology by race and ethnicity among women 50 years of age and older. Cancer Epidemiol Biomarkers Prev. 2002;11:601–607
  19. Li CI, Malone KE, Daling JR. Differences in breast cancer stage, treatment, and survival by race and ethnicity. Arch Intern Med. 2003;163:49–56
  20. Shavers VL, Harlan LC, Stevens JL. Racial/ethnic variation in clinical presentation, treatment, and survival among breast cancer patients under age 35. Cancer. 2003;97:134–147
  21. Elledge RM, Clark GM, Chamness GC, Osborne CK. Tumor biologic factors and breast cancer prognosis among white, Hispanic, and black women in the United States. J Natl Cancer Inst. 1994;86:705–712
  22. Boyer-Chammard A, Taylor TH, Anton-Culver H. Survival differences in breast cancer among racial/ethnic groups: a population-based study. Cancer Detect Prev. 1999;23:463–473
  23. Clegg LX, Li FP, Hankey BF, Chu K, Edwards BK. Cancer survival among US whites and minorities: a SEER (Surveillance, Epidemiology, and End Results) Program population-based study. Arch Intern Med. 2002;162:1985–1993
  24. Ries L, Eisner M, Kosary C, Hankey B, Miller B, Clegg L, et al. SEER Cancer Statistics Review, 1975-2002. NCI; 2005;
  25. Anderson WF, Chatterjee N, Ershler WB, Brawley OW. Estrogen receptor breast cancer phenotypes in the Surveillance, Epidemiology, and End Results database. Breast Cancer Res Treat. 2002;76:27–36
  26. Key T, Appleby P, Reeves G. Endogenous sex hormones and breast cancer in postmenopausal women: reanalysis of nine prospective studies. J Natl Cancer Inst. 2002;94:606–616
  27. Missmer SA, Eliassen AH, Barbieri RL, Hankinson SE. Endogenous estrogen, androgen, and progesterone concentrations and breast cancer risk among postmenopausal women. J Natl Cancer Inst. 2004;96:1856–1865
  28. Cauley JA, Lucas FL, Kuller LH, Stone K, Browner W, Cummings SR. Elevated serum estradiol and testosterone concentrations are associated with a high risk for breast cancer (Study of Osteoporotic Fractures Research Group). Ann Intern Med. 1999;130:270–277
  29. Cummings SR, Lee JS, Lui LY, Stone K, Ljung BM, Cauleys JA. Sex hormones, risk factors, and risk of estrogen receptor-positive breast cancer in older women: a long-term prospective study. Cancer Epidemiol Biomarkers Prev. 2005;14:1047–1051
  30. Pathak DR, Osuch JR, He J. Breast carcinoma etiology: current knowledge and new insights into the effects of reproductive and hormonal risk factors in black and white populations. Cancer. 2000;88:1230–1238
  31. Palmer JR, Wise LA, Horton NJ, Adams-Campbell LL, Rosenberg L. Dual effect of parity on breast cancer risk in African-American women. J Natl Cancer Inst. 2003;95:478–483
  32. Ursin G, Bernstein L, Wang Y, Lord SJ, Deapen D, Liff JM, et al. Reproductive factors and risk of breast carcinoma in a study of white and African-American women. Cancer. 2004;101:353–362
  33. Kovi J, Mohla S, Norris HJ, Sampson CC, Heshmat MY. Breast lesions in black women. Pathol Annu. 1989;24:199–218
  34. Natarajan N, Nemoto T, Mettlin C, Murphy GP. Race-related differences in breast cancer patients (Results of the 1982 national survey of breast cancer by the American College of Surgeons). Cancer. 1985;56:1704–1709
  35. Trock BJ. Breast cancer in African American women: epidemiology and tumor biology. Breast Cancer Res Treat. 1996;40:11–24
  36. Middleton LP, Chen V, Perkins GH, Pinn V, Page D. Histopathology of breast cancer among African-American women. Cancer. 2003;97:253–257
  37. Hance KW, Anderson WF, Devesa SS, Young HA, Levine PH. Trends in inflammatory breast carcinoma incidence and survival: The Surveillance, Epidemiology, and End Results Program at the National Cancer Institute. J Natl Cancer Inst. 2005;97:966–975
  38. Joslyn SA, Foote ML, Nasseri K, Coughlin SS, Howe HL. Racial and ethnic disparities in breast cancer rates by age: NAACCR Breast Cancer Project. Breast Cancer Res Treat. 2005;92:97–105
  39. Jones BA, Kasl SV, Howe CL, Lachman M, Dubrow R, Curnen MM, et al. African-American/White differences in breast carcinoma: p53 alterations and other tumor characteristics. Cancer. 2004;101:1293–1301
  40. Porter PL, Lund MJ, Lin MG, Yuan X, Liff JM, Flagg EW, et al. Racial differences in the expression of cell cycle-regulatory proteins in breast carcinoma. Cancer. 2004;100:2533–2542
  41. Stark AT, Claud S, Kapke A, Lu M, Linden M, Griggs J. Race modifies the association between breast carcinoma pathologic prognostic indicators and the positive status for HER-2/neu. Cancer. 2005;104:2189–2196
  42. Jatoi I, Anderson WF, Rao SR, Devesa SS. Breast cancer trends among black and white women in the United States. J Clin Oncol. 2005;23:7836–7841
  43. Muss HB, Hunter CP, Wesley M, Correa P, Chen VW, Greenberg RS, et al. Treatment plans for black and white women with stage II node-positive breast cancer (The National Cancer Institute Black/White Cancer Survival Study experience). Cancer. 1992;70:2460–2467
  44. Tammemagi CM, Nerenz D, Neslund-Dudas C, Feldkamp C, Nathanson D. Comorbidity and survival disparities among black and white patients with breast cancer. J Am Med Assoc. 2005;294:1765–1772
  45. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, et al. Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med. 2002;347:1233–1241
  46. Veronesi U, Cascinelli N, Mariani L, Greco M, Saccozzi R, Luini A, et al. Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med. 2002;347:1227–1232
  47. Early Breast Cancer Trialists’ Collaborative Group. Polychemotherapy for early breast cancer: an overview of the randomised trials. Lancet. 1998;352:930–942
  48. Early Breast Cancer Trialists’ Collaborative Group. Tamoxifen for early breast cancer: an overview of the randomised trials. Lancet. 1998;351:1451–1467
  49. Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet. 2005;365:1687–1717
  50. White J, Morrow M, Moughan J, Owen J, Pajak T, DesHarnais S, et al. Compliance with breast-conservation standards for patients with early-stage breast carcinoma. Cancer. 2003;97:893–904
  51. Bickell NA, Wang JJ, Oluwole S, Schrag D, Godfrey H, Hiotis K, et al. Missed opportunities: racial disparities in adjuvant breast cancer treatment. J Clin Oncol. 2006;24:1357–1362
  52. Hershman D, McBride R, Jacobson JS, Lamerato L, Roberts K, Grann VR, et al. Racial disparities in treatment and survival among women with early-stage breast cancer. J Clin Oncol. 2005;23:6639–6646
  53. Hershman D, Weinberg M, Rosner Z, Alexis K, Tiersten A, Grann VR, et al. Ethnic neutropenia and treatment delay in African American women undergoing chemotherapy for early-stage breast cancer. J Natl Cancer Inst. 2003;95:1545–1548
  54. Maggard MA, Lane KE, O’Connell JB, Nanyakkara DD, Ko CY. Beyond the clinical trials: how often is sentinel lymph node dissection performed for breast cancer?. Ann Surg Oncol. 2005;12:41–47
  55. Morrow M, Scott SK, Menck HR, Mustoe TA, Winchester DP. Factors influencing the use of breast reconstruction postmastectomy: a National Cancer Database study. J Am Coll Surg. 2001;192:1–8
  56. Alderman AK, McMahon L, Wilkins EG. The national utilization of immediate and early delayed breast reconstruction and the effect of sociodemographic factors. Plast Reconstr Surg. 2003;111:695–703discussion 704-5
  57. Tseng JF, Kronowitz SJ, Sun CC, Perry AC, Hunt KK, Babiera GV, et al. The effect of ethnicity on immediate reconstruction rates after mastectomy for breast cancer. Cancer. 2004;101:1514–1523
  58. Simon MS, Du W, Flaherty L, Philip PA, Lorusso P, Miree C, et al. Factors associated with breast cancer clinical trials participation and enrollment at a large academic medical center. J Clin Oncol. 2004;22:2046–2052
  59. Adams-Campbell LL, Ahaghotu C, Gaskins M, Dawkins FW, Smoot D, Polk OD, et al. Enrollment of African Americans onto clinical treatment trials: study design barriers. J Clin Oncol. 2004;22:730–734
  60. Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst. 1998;90:1371–1388
  61. Gail M, Costantino J, Bryant J, Croyle R, Freedman L, Helzslouer K, et al. Weighing the risks and benefits of tamoxifen treatment for preventing breast cancer. J Natl Cancer Inst. 1999;91:1829–1846
  62. Gail MH, Brinton LA, Byar DP, Corle DK, Green SB, Schairer C, et al. Projecting individualized probabilities of developing breast cancer for white females who are being examined annually. J Natl Cancer Inst. 1989;81:1879–1886
  63. Newman LA, Rockhill B, Bondy ML, Abrams JA, Berlin JA, Colditz GA, et al. Validation of the Gail Breast Cancer risk assessment model in African American women based on a multi-center case-control study of 3,283 African American and 5,974 White American women. 2002;American Society of Clinical Oncology, 38th Annual Meeting. Orlando, Florida, ASCO, pp Abstract #976
  64. Newman LA, Gail MH, Selvan M, Bondy M, Rockhill B, Colditz GA, et al. Proposed revision of the Gail breast cancer risk assessment model for African American women. 2003;American Society of Clinical Oncology, 39th Annual Meeting. Chicago, IL
  65. Newman LA, Lee CT, Parekh LP, Stewart AK, Thomas CR, Beltran RA, et al. Use of the National Cancer Data Base to develop clinical trials accrual targets that are appropriate for minority ethnicity patients. Cancer. 2006;106:188–195
  66. Fisher ER, Redmond C, Fisher B, Bass G. Pathologic findings from the National Surgical Adjuvant Breast and Bowel Projects (NSABP) (Prognostic discriminants for 8-year survival for node-negative invasive breast cancer patients). Cancer. 1990;65:2121–2128
  67. Dignam JJ. Differences in breast cancer prognosis among African-American and Caucasian women. CA Cancer J Clin. 2000;50:50–64
  68. Dignam JJ. Efficacy of systemic adjuvant therapy for breast cancer in African-American and Caucasian women. J Natl Cancer Inst Monogr. 2001;36–43
  69. McCaskill-Stevens W, Wilson J, Bryant J, Mamounas E, Garvey L, James J, et al. Contralateral breast cancer and thromboembolic events in African American women treated with tamoxifen. J Natl Cancer Inst. 2004;96:1762–1769
  70. Roach M, Cirrincione C, Budman D, Hayes D, Berry D, Younger J, et al. Race and survival from breast cancer: based on Cancer and Leukemia Group B trial 8541. Cancer J Sci Am. 1997;3:107–112
  71. Unger J, Coltman C, Appelbaum F, Barlogie B, Crawford E, Fisher R, et al. African Americans have worse survival in hormone-related cancers (A Southwest Oncology Group (SWOG) study). Proc Am Soc Clin Oncol. 2003;22:529
  72. Albain K, Unger J, Hutchins L, Rivkin S, Martino S, Livingston R, et al. Outcome of African Americans on Southwest Oncology Group (SWOG) breast cancer adjuvant therapy trials. 2003;Abstract #21, 2003 San Antonio Breast Cancer Symposium. San Antonio, TX
  73. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, et al. Risks and benefits of estrogen plus progestin in healthy postmenopausal women: principal results From the Women’s Health Initiative randomized controlled trial. J Am Med Assoc. 2002;288:321–333
  74. Chlebowski RT, Chen Z, Anderson GL, Rohan T, Aragaki A, Lane D, et al. Ethnicity and breast cancer: factors influencing differences in incidence and outcome. J Natl Cancer Inst. 2005;97:439–448
  75. U.S. Census Bureau, Current Population Survey, 2002 to 2004. Annual Social and Economic Supplements, 2004.
  76. Newman LA, Griffith KA, Jatoi I, Simon MS, Crowe JP, Colditz GA. Meta-analysis of survival in African American and white American patients with breast cancer: ethnicity compared with socioeconomic status. J Clin Oncol. 2006;24:1342–1349
  77. Newman LA, Bunner S, Carolin K, Bouwman D, Kosir MA, White M, et al. Ethnicity related differences in the survival of young breast carcinoma patients. Cancer. 2002;95:21–27
  78. Connor CS, Touijer AK, Krishnan L, Mayo MS. Local recurrence following breast conservation therapy in African-American women with invasive breast cancer. Am J Surg. 2000;179:22–26
  79. Nicolaou N, Fowble B, Hanlon A. In: The impact of regional lymphatic irradiation and of the extent of axillary lymph node dissection on regional control in patients with early-stage, node-positive breast cancer, treated with breast-conserving therapy, Abstract #266. American Society of Clinical Oncology; 1999;p. 71a
  80. Velanovich V, Yood MU, Bawle U, Nathanson SD, Strand VF, Talpos GB, et al. Racial differences in the presentation and surgical management of breast cancer. Surgery. 1999;125:375–379
  81. Arnold RE, Frykberg ER, Kilkenny JW, Bowers GJ, Mierzejewski J. Trends in surgical treatment of breast cancer at an urban teaching hospital: a six-year review. Am Surg. 1998;64:107–111
  82. Pierce L, Fowble B, Solin LJ, Schultz DJ, Rosser C, Goodman RL. Conservative surgery and radiation therapy in black women with early stage breast cancer (Patterns of failure and analysis of outcome). Cancer. 1992;69:2831–2841

PII: S0147-0272(07)00004-9

doi: 10.1016/j.currproblcancer.2007.01.003

Current Problems in Cancer
Volume 31, Issue 3 , Pages 134-156 , May 2007