« Previous
Current Problems in Cancer
Volume 31, Issue 2
, Pages 36-100
, March 2007
Tumor Microenvironment Promotes Cancer Progression, Metastasis, and Therapeutic Resistance
References
- . Prostate tumor-stroma interaction: molecular mechanisms and opportunities for therapeutic targeting. Differentiation. 2002;70(9-10):506–521
- . Metallothionein expression in prostatic carcinoma: correlation with Gleason grade, pathologic stage, DNA content and serum level of prostate-specific antigen. Clin Invest Med. 1997;20(6):371–380
- Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness. Prostate. 2006;66(3):317–325
- Intravascular metastatic cancer cell homotypic aggregation at the sites of primary attachment to the endothelium. Cancer Res. 2003;63(13):3805–3811
- . Mechanisms of bone metastasis. Cancer. 1997;80(8):1546–1556(suppl).
- Detection of circulating prostate cells by reverse transcriptase-polymerase chain reaction of human glandular kallikrein (hK2) and prostate-specific antigen (PSA) messages. Urology. 1997;50(2):184–188
- . Pathways of metastatic spread of malignant tumors. Semin Oncol. 1977;4(1):33–38
- Increased expression of apoptosis inhibitor protein XIAP contributes to anoikis resistance of circulating human prostate cancer metastasis precursor cells. Cancer Res. 2005;65(6):2378–2386
- . Tumor metastasis: mechanistic insights and clinical challenges. Nat Med. 2006;12(8):895–904
- . Tumor-microenvironment interactions: the selectin-selectin ligand axis in tumor-endothelium cross talk. Cancer Treat Res. 2006;130:125–140
- . Progress in molecular mechanisms of tumor metastasis and angiogenesis. Anticancer Res. 2005;25(5):3327–3333
- LNCaP progression model of human prostate cancer: androgen-independence and osseous metastasis. Prostate. 2000;44(2):91–103
- . Derivation of androgen-independent human LNCaP prostatic cancer cell sublines: role of bone stromal cells. Int J Cancer. 1994;57(3):406–412
- Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel. In Vitro Cell Dev Biol Anim. 2001;37(3):127–140
- Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone. Semin Cancer Biol. 2005;15(5):353–364
- . Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res. 1999;59(19):5002–5011
- . Growth factors and epithelial-stromal interactions in prostate cancer development. Int Rev Cytol. 2000;199:65–116
- . Context, tissue plasticity, and cancer: are tumor stem cells also regulated by the microenvironment?. Cancer Cell. 2005;7(1):17–23
- . Putting tumours in context. Nat Rev Cancer. 2001;1(1):46–54
- Restoration of epithelial cell polarity in a colorectal cancer cell line by suppression of beta-catenin/T-cell factor 4-mediated gene transactivation. Cancer Res. 2001;61(6):2751–2758
- . Molecular insights into prostate cancer progression: the missing link of tumor microenvironment. J Urol. 2005;173(1):10–20
- . Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell. 2005;123(6):1001–1011
- Prostate stromal cell-derived hepatocyte growth factor induces invasion of prostate cancer cell line DU145 through tumor-stromal interaction. Prostate. 1999;41(3):145–153
- Oxidative stress induces ADAM9 protein expression in human prostate cancer cells. Cancer Res. 2006;66(19):9519–9526
- . Reactive stroma in human prostate cancer: induction of myofibroblast phenotype and extracellular matrix remodeling. Clin Cancer Res. 2002;8(9):2912–2923
- . Tumour-stroma interactions between metastatic prostate cancer cells and fibroblasts. Int J Mol Med. 2006;18(5):941–950
- . In: Invasive Prostate Cancer Cells Secrete Soluble Protein Factors That Upregulate Osteocalcin (OC) Promoter Activity: Implication to Stroma Desmoplastic Response and Cancer Metastasis. AUA Annual Conference 2003. Chicago, IL: Journal of Urology; 2003;p. 154
- . The desmoplastic response to infiltrating breast carcinoma: gene expression at the site of primary invasion and implications for comparisons between tumor types. Cancer Res. 2002;62(18):5351–5357
- . Severe combined immunodeficient-hu model of human prostate cancer metastasis to human bone. Cancer Res. 1999;59(8):1987–1993
- . Tenascin expression at the invasive front is associated with poor prognosis in intrahepatic cholangiocarcinoma. Mod Pathol. 2003;16(10):1019–1027
- Biglycan is overexpressed in pancreatic cancer and induces G1-arrest in pancreatic cancer cell lines. Gastroenterology. 2001;121(3):657–667
- . Altered extracellular matrices influence cellular processes and nuclear matrix organizations of overlying human bladder urothelial cells. Cancer Res. 1993;53(20):4971–4977
- . Bone extracellular matrix induces homeobox proteins independent of androgens: possible mechanism for androgen-independent growth in human prostate cancer cells. Prostate. 1996;29(6):362–370
- . Profiling molecular targets of TGF-beta1 in prostate fibroblast-to-myofibroblast transdifferentiation. Mech Ageing Dev. 2005;126(1):59–69
- Elevated levels of versican but not decorin predict disease progression in early-stage prostate cancer. Clin Cancer Res. 1998;4(4):963–971
- The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. Prostate. 2005;63(3):269–275
- Modulation of prostate cancer cell attachment to matrix by versican. Cancer Res. 2003;63(16):4786–4791
- Reactive stroma as a predictor of biochemical-free recurrence in prostate cancer. Clin Cancer Res. 2003;9(13):4792–4801
- . Concurrent and independent genetic alterations in the stromal and epithelial cells of mammary carcinoma: implications for tumorigenesis. Cancer Res. 2000;60(9):2562–2566
- Prostate cancer metastasis: role of the host microenvironment in promoting epithelial to mesenchymal transition and increased bone and adrenal gland metastasis. Prostate. 2006;66(15):1664–1673
- . Malignant breast epithelium selects for insulin-like growth factor II expression in breast stroma: evidence for paracrine function. Cancer Res. 1995;55(11):2448–2454
- . The role of stromal-epithelial interaction in normal and malignant growth. Cancer Surv. 1995;23:33–42
- . The causes and prevention of cancer. Proc Natl Acad Sci U S A. 1995;92(12):5258–5265
- . Epidemiology of inflammation and prostate cancer. J Urol. 2004;171(2 Pt 2):S36–S40
- . The role of inflammation in the pathogenesis of prostate cancer. J Urol. 2004;172(5 Pt 2):S6–S11discussion S-2
- . Proliferative inflammatory atrophy of the prostate: implications for prostatic carcinogenesis. Am J Pathol. 1999;155(6):1985–1992
- Cyclooxygenase-2 is up-regulated in proliferative inflammatory atrophy of the prostate, but not in prostate carcinoma. Cancer Res. 2001;61(24):8617–8623
- Distribution of chronic prostatitis in radical prostatectomy specimens with up-regulation of bcl-2 in areas of inflammation. J Urol. 2002;167(5):2267–2270
- . Intraepithelial and stromal lymphocytes in the normal human prostate. Prostate. 2003;55(3):187–193
- . The effect of chemical carcinogenesis on rat glutathione S-transferase P1 gene transcriptional regulation. Mol Biol Rep. 2001;28(1):19–25
- . Oxidative stress increases frameshift mutations in human colorectal cancer cells. Cancer Res. 2001;61(20):7444–7448
- . H2O2 oxidative damage in cultured oral epithelial cells: the effect of short-term vitamin C exposure. Anticancer Res. 2001;21(4A):2719–2724
- . Reactive stroma in prostate cancer progression. J Urol. 2001;166(6):2472–2483
- . Basement membranes in fetal, adult normal, hyperplastic and neoplastic human prostate. Virchows Arch A Pathol Anat Histopathol. 1991;418(5):375–381
- . Prostate epithelial differentiation is dictated by its surrounding stroma. Mol Biol Rep. 1996;23(1):13–19
- Stromal-epithelial interaction in prostate cancer progression. Clin Genitourin Cancer. 2006;5(2):162–170
- . Role of stromal-epithelial interactions in hormonal responses. Arch Histol Cytol. 2004;67(5):417–434
- . Role of stroma in carcinogenesis of the prostate. Differentiation. 2002;70(9-10):473–485
- . Stromal-epithelial interactions (II. Regulation of prostatic growth by embryonic urogenital sinus mesenchyme). Prostate. 1983;4(5):503–511
- . Cotargeting tumor and stroma in a novel chimeric tumor model involving the growth of both human prostate cancer and bone stromal cells. Cancer Gene Ther. 2004;11(2):148–155
- . Acceleration of human prostate cancer growth in vivo by factors produced by prostate and bone fibroblasts. Cancer Res. 1991;51(14):3753–3761
- . Prostate and bone fibroblasts induce human prostate cancer growth in vivo: implications for bidirectional tumor-stromal cell interaction in prostate carcinoma growth and metastasis. J Urol. 1992;147(4):1151–1159
- . A fetal rat urogenital sinus mesenchymal cell line (rUGM): accelerated growth and conferral of androgen-induced growth responsiveness upon a human bladder cancer epithelial cell line in vivo. Int J Cancer. 1994;56(5):706–714
- . Prostate carcinoma bone-stroma interaction and its biologic and therapeutic implications. Cancer. 2003;97(3):772–778(suppl).
- . Preclinical studies with zoledronic acid and other bisphosphonates: impact on the bone microenvironment. Semin Oncol. 2001;28(2):35–44(suppl 6).
- . Tumor-bone cellular interactions in skeletal metastases. J Musculoskelet Neuronal Interact. 2004;4(3):308–318
- . What might a stromal response mean to prostate cancer progression?. Cancer Metastasis Rev. 1998;17(4):411–419
- . Stromal expression of connective tissue growth factor promotes angiogenesis and prostate cancer tumorigenesis. Cancer Res. 2005;65(19):8887–8895
- The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer. Clin Cancer Res. 2005;11(21):7658–7663
- . Androgens stimulate hypoxia-inducible factor 1 activation via autocrine loop of tyrosine kinase receptor/phosphatidylinositol 3′-kinase/protein kinase B in prostate cancer cells. Clin Cancer Res. 2003;9(7):2416–2425
- Reactive oxygen species regulate insulin-induced VEGF and HIF-1{alpha} expression through the activation of p70S6K1 in human prostate cancer cells. Carcinogenesis. 2007;28(1):28–37
- Vascular endothelial growth factor-A expression in the rat ventral prostate gland and the early effects of castration. Prostate. 2000;43(3):184–194
- Reactive oxygen species as downstream mediators of angiogenic signaling by vascular endothelial growth factor receptor-2/KDR. J Biol Chem. 2002;277(5):3101–3108
- . Genomic instability and cancer. Curr Mol Med. 2003;3(7):589–596
- . Adhesion molecules in cancer: the role of integrins. Curr Opin Cell Biol. 1993;5(5):812–818
- . Focal adhesion kinase and its potential involvement in tumor invasion and metastasis. Head Neck. 1998;20(8):745–752
- . Integrin-mediated cell-matrix interactions for prosurvivaland antiapoptotic signaling after genotoxic injury. Cancer Lett. 2006;242(1):11–19
- Increased resistance of tumor cells to hyperthermia mediated by integrin-linked kinase. Clin Cancer Res. 2003;9(3):1155–1160
- Integrin expression and usage by prostate cancer cell lines on laminin substrata. Cell Growth Differ. 2001;12(2):99–107
- . Substrate specificity of alpha(v)beta(3) integrin-mediated cell migration and phosphatidylinositol 3-kinase/AKT pathway activation. J Biol Chem. 2000;275(32):24565–24574
- . Prostatic carcinoma cell migration via alpha(v) beta3 integrin is modulated by a focal adhesion kinase pathway. Cancer Res. 1999;59(7):1655–1664
- . A bidirectional “alpha(v)beta(3) integrin-ERK1/ERK2 MAPK” connection regulates the proliferation of breast cancer cells. Mol Carcinog. 2006;45(10):795–804
- . Pressure activates colon cancer cell adhesion by inside-out focal adhesion complex and actin cytoskeletal signaling. Gastroenterology. 2004;126(1):8–18
- . AlphaVbeta3 integrin regulates heregulin (HRG)-induced cell proliferation and survival in breast cancer. Oncogene. 2005;24(23):3759–3773
- . Fibroblast growth factor 2: its structure and property, paracrine function, tumor angiogenesis, and prostate-related mitogenic and oncogenic functions. Urology. 2000;55(6):800–806
- . Alterations in expression of basic fibroblast growth factor (FGF) 2 and its receptor FGFR-1 in human prostate cancer. Clin Cancer Res. 1999;5(5):1063–1071
- . Stromal cell heterogeneity in fibroblast growth factor-mediated stromal-epithelial cell cross-talk in premalignant prostate tumors. Cancer Res. 2003;63(16):4936–4944
- . The role of fibroblast growth factors and their receptors in prostate cancer. Endocr Relat Cancer. 2004;11(4):709–724
- . Thrombospondin-1, vascular endothelial growth factor and fibroblast growth factor-2 are key functional regulators of angiogenesis in the prostate. Prostate. 2001;49(4):293–305
- . Correlation of vascular endothelial growth factor expression with fibroblast growth factor-8 expression and clinico-pathologic parameters in human prostate cancer. Br J Cancer. 2001;85(4):576–583
- . Fibroblast growth factor 2 activation of stromal cell vascular endothelial growth factor expression and angiogenesis. Lab Invest. 2001;81(1):61–75
- . Exon switching and activation of stromal and embryonic fibroblast growth factor (FGF)-FGF receptor genes in prostate epithelial cells accompany stromal independence and malignancy. Mol Cell Biol. 1993;13(8):4513–4522
- . Constitutive production of platelet-derived growth factor-like proteins by human prostate carcinoma cell lines. Cancer Res. 1988;48(7):1930–1935
- . Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis. Development. 1992;115(1):123–131
- . Retinal glial cells stimulate microvascular pericyte proliferation via fibroblast growth factor and platelet-derived growth factor in vitro. Jpn J Ophthalmol. 2002;46(4):413–418
- . PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis. Dev Dyn. 2002;223(1):155–162
- . Effects of embryotrophic factors on the embryogenesis and organogenesis of mouse embryos in vitro. Hum Cell. 2000;13(4):185–195
- . Early growth response factor 1: a pleiotropic mediator of inducible gene expression. J Mol Med. 1998;76(9):613–616
- . Immunohistochemistry analysis of platelet-derived growth factor A and B chains and platelet-derived growth factor alpha and beta receptor expression in benign prostatic hyperplasias and Gleason-graded human prostate adenocarcinomas. Mod Pathol. 1994;7(5):549–554
- Platelet-derived growth factor induces proliferation of hyperplastic human prostatic stromal cells. J Cell Biochem. 1993;52(4):404–413
- c-MYC deregulation is involved in melphalan resistance of multiple myeloma: role of PDGF-BB. Int J Immunopathol Pharmacol. 2006;19(1):67–79
- Vascular endothelial growth factor (VEGF) expression in human prostate cancer: in situ and in vitro expression of VEGF by human prostate cancer cells. J Urol. 1997;157(6):2329–2333
- . Signaling vascular morphogenesis and maintenance. Science. 1997;277(5322):48–50
- A potential autocrine role for vascular endothelial growth factor in prostate cancer. Cancer Res. 2002;62(3):854–859
- . Vascular endothelial growth factor-mediated autocrine stimulation of prostate tumor cells coincides with progression to a malignant phenotype. Am J Pathol. 2001;159(2):651–659
- Reactive oxygen generated by Nox1 triggers the angiogenic switch. Proc Natl Acad Sci U S A. 2002;99(2):715–720
- . Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth. Exp Cell Res. 1999;253(1):88–99
- Macrophage stimulating protein (MSP) evokes superoxide anion production by human macrophages of different origin. Br J Pharmacol. 2001;134(6):1285–1295
- Macrophage-stimulating protein is produced by tubular cells and activates mesangial cells. J Am Soc Nephrol. 2002;13(3):649–657
- Hepatocyte growth factor and macrophage-stimulating protein are upregulated during excisional wound repair in rats. Cell Tissue Res. 2001;306(2):239–250
- . Invasive growth: from development to metastasis. J Clin Invest. 2002;109(7):857–862
- . Expression of hepatocyte growth factor/scatter factor, its activator, inhibitors and the c-Met receptor in human cancer cells. Int J Oncol. 2001;19(4):857–863
- . Functional characterization of Kunitz domains in hepatocyte growth factor activator inhibitor type 1. J Biol Chem. 2002;277(16):14053–14059
- Regulation of invasive potential of human prostate cancer cell lines by hepatocyte growth factor. Int J Urol. 1998;5(3):276–281
- . Overexpression and regulation of expression of scatter factor/hepatocyte growth factor in prostatic carcinoma. Urology. 2000;56(6):1071–1074
- Normal and malignant prostate epithelial cells differ in their response to hepatocyte growth factor/scatter factor. Am J Pathol. 2001;159(2):579–590
- . HGF/SF modifies the interaction between its receptor c-Met, and the E-cadherin/catenin complex in prostate cancer cells. Int J Mol Med. 2001;7(4):385–388
- . Matrilysin mediates extracellular cleavage of E-cadherin from prostate cancer cells: a key mechanism in hepatocyte growth factor/scatter factor-induced cell-cell dissociation and in vitro invasion. Clin Cancer Res. 2001;7(10):3289–3297
- Effects of hepatocyte growth factor on E-cadherin-mediated cell-cell adhesion in DU145 prostate cancer cells. Urology. 2001;58(6):1064–1069
- Regulation of migration of primary prostate epithelial cells by secreted factors from prostate stromal cells. Exp Cell Res. 2003;288(2):246–256
- . Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst. 1974;52(2):413–427
- . How is blood vessel growth regulated in normal and neoplastic tissue? (G.H.A. Clowes memorial Award lecture). Cancer Res. 1986;46(2):467–473
- . Angiogenesis inhibition: a review. Pharmacol Ther. 1994;63(3):265–311
- . The organ microenvironment and cancer metastasis. Differentiation. 2002;70(9-10):498–505
- . Angiogenesis in cancer and other diseases. Nature. 2000;407(6801):249–257
- . Molecular regulation of vessel maturation. Nat Med. 2003;9(6):685–693
- . Vascular-specific growth factors and blood vessel formation. Nature. 2000;407(6801):242–248
- . The biology of VEGF and its receptors. Nat Med. 2003;9(6):669–676
- . The relevance of cell proliferation, vascular endothelial growth factor, and basic fibroblast growth factor production to angiogenesis and tumorigenicity in human glioma cell lines. Clin Cancer Res. 2000;6(6):2562–2572
- . Growth factor regulation of neutrophil-endothelial cell interactions. J Leukoc Biol. 2001;70(2):225–232
- Vascular endothelial growth factor increases urokinase receptor expression in vascular endothelial cells. J Biol Chem. 1995;270(17):9709–9716
- . Vascular endothelial growth factor (VEGF) induces rapid prourokinase (pro-uPA) activation on the surface of endothelial cells. Blood. 2004;103(3):955–962
- Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor. Nature. 1989;338(6216):557–562
- Hepatocyte growth factor is a potent angiogenic factor which stimulates endothelial cell motility and growth. J Cell Biol. 1992;119(3):629–641
- Platelet-derived growth factor is angiogenic in vivo. Growth Factors. 1992;7(4):261–266
- Promotion of angiogenesis by ps20 in the differential reactive stroma prostate cancer xenograft model. Cancer Res. 2003;63(18):5859–5865
- Androgens modulate the balance between VEGF and angiopoietin expression in prostate epithelial and smooth muscle cells. Prostate. 2002;50(2):83–91
- Vascular endothelial growth factor and p53 expressions in liver and abdominal metastases from colon cancer. Tumour Biol. 2003;24(2):77–81
- Differences of vascular endothelial growth factor (VEGF) expression between liver and abdominal metastases from colon cancer (Implications for the treatment with VEGF inhibitors). Clin Exp Metastasis. 2000;18(8):651–655
- . The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev. 1999;20(2):189–206
- . CCN proteins are distinct from and should not be considered members of the insulin-like growth factor-binding protein superfamily. Endocrinology. 2000;141(6):2254–2256
- . The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res. 1999;248(1):44–57
- . Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol. 1991;114(6):1285–1294
- . Structure, mapping, and expression of fisp-12, a growth factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 1991;2(5):225–233
- . Expression of cyr61, a growth factor-inducible immediate-early gene. Mol Cell Biol. 1990;10(7):3569–3577
- Physical mapping of human loci homologous to the chicken nov proto-oncogene. Oncogene. 1992;7(12):2529–2534
- WISP genes are members of the connective tissue growth factor family that are up-regulated in wnt-1-transformed cells and aberrantly expressed in human colon tumors. Proc Natl Acad Sci U S A. 1998;95(25):14717–14722
- . CTGF expression is induced by TGF- beta in cardiac fibroblasts and cardiac myocytes: a potential role in heart fibrosis. J Mol Cell Cardiol. 2000;32(10):1805–1819
- . Stimulation of fibroblast cell growth, matrix production, and granulation tissue formation by connective tissue growth factor. J Invest Dermatol. 1996;107(3):404–411
- . A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ. 1996;7(4):469–480
- . Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Biol Cell. 1993;4(6):637–645
- Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J. 1999;13(13):1774–1786
- CCN2 (connective tissue growth factor) promotes fibroblast adhesion to fibronectin. Mol Biol Cell. 2004;15(12):5635–5646
- . Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro. Eur J Cell Biol. 2000;79(12):915–923
- . Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo. Mol Cell Biol. 1999;19(4):2958–2966
- . Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61). Angiogenesis. 2002;5(3):153–165
- Connective tissue growth factor induces the proliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo. J Biochem (Tokyo). 1999;126(1):137–145
- . Expression of connective tissue growth factor mRNA in the fibrous stroma of mammary tumors. Int J Biochem Cell Biol. 1997;29(1):153–161
- Connective tissue growth factor gene expression alters tumor progression in esophageal cancer. World J Surg. 2002;26(4):420–427
- Expression and differential regulation of connective tissue growth factor in pancreatic cancer cells. Oncogene. 1999;18(4):1073–1080
- . Connective tissue growth factor expression in pediatric myofibroblastic tumors. Pediatr Dev Pathol. 2001;4(1):37–45
- Expression of connective tissue growth factor in cartilaginous tumors. Cancer. 2000;89(7):1466–1473
- . Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy?. Matrix Biol. 2002;21(6):473–482
- . Morphogenetic roles of classic cadherins. Curr Opin Cell Biol. 1995;7(5):619–627
- . Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. Genes Dev. 2000;14(10):1169–1180
- . Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta. 1994;1198(1):11–26
- . Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 1991;66(1):107–119
- . A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998;392(6672):190–193
- . Dynamics of intercellular communication during melanoma development. Mol Med Today. 2000;6(4):163–169
- Cadherin switching in human prostate cancer progression. Cancer Res. 2000;60(13):3650–3654
- . Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol. 2000;148(4):779–790
- . Expression of N-cadherin by human squamous carcinoma cells induces a scattered fibroblastic phenotype with disrupted cell-cell adhesion. J Cell Biol. 1996;135(6 Pt 1):1643–1654
- . N-cadherin-mediated intercellular interactions promote survival and migration of melanoma cells. Cancer Res. 2001;61(9):3819–3825
- . N-cadherin promotes motility in human breast cancer cells regardless of their E-cadherin expression. J Cell Biol. 1999;147(3):631–644
- . Early epochal maps of two different cell adhesion molecules. Proc Natl Acad Sci U S A. 1983;80(14):4384–4388
- . Expression of N-cadherin adhesion molecules associated with early morphogenetic events in chick development. Nature. 1986;320(6061):447–449
- . The transcription factor Slug represses E-cadherin expression and induces epithelial to mesenchymal transitions: a comparison with Snail and E47 repressors. J Cell Sci. 2003;116(Pt 3):499–511
- . A conserved DpYR motif in the juxtamembrane domain of the Met receptor family forms an atypical c-Cbl/Cbl-b tyrosine kinase binding domain binding site required for suppression of oncogenic activation. J Biol Chem. 2004;279(28):29565–29571
- . The dietary phytochemical chlorophyllin alters E-cadherin and beta-catenin expression in human colon cancer cells. J Nutr. 2004;134(12):3441S–3444S(suppl).
- Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex. Nat Cell Biol. 2002;4(3):222–231
- . CAM-FGF receptor interactions: a model for axonal growth. Mol Cell Neurosci. 1996;8(2/3):99–111
- . A signaling pathway leading to metastasis is controlled by N-cadherin and the FGF receptor. Cancer Cell. 2002;2(4):301–314
- . N-CAM modulates tumour-cell adhesion to matrix by inducing FGF-receptor signalling. Nat Cell Biol. 2001;3(7):650–657
- . The molecular organization of endothelial junctions and their functional role in vascular morphogenesis and permeability. Int J Dev Biol. 2000;44(6):743–748
- Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. Cell. 1999;98(2):147–157
- . Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells. J Cell Sci. 1998;111(Pt 13):1853–1865
- . Developmental roles of HGF/SF and its receptor, the c-Met tyrosine kinase. Trends Cell Biol. 1998;8(10):404–410
- . CD44: from adhesion molecules to signalling regulators. Nat Rev Mol Cell Biol. 2003;4(1):33–45
- . The CD44 protein family. Int J Biochem Cell Biol. 1998;30(3):299–305
- How tumor cells make use of CD44. Cell Adhes Commun. 1998;6(2-3):141–147
- . CD44 is required for two consecutive steps in HGF/c-Met signaling. Genes Dev. 2002;16(23):3074–3086
- . CD44 anchors the assembly of matrilysin/MMP-7 with heparin-binding epidermal growth factor precursor and ErbB4 and regulates female reproductive organ remodeling. Genes Dev. 2002;16(3):307–323
- . Linking colorectal cancer to Wnt signaling. Cell. 2000;103(2):311–320
- . An overview of epithelio-mesenchymal transformation. Acta Anat (Basel). 1995;154(1):8–20
- . Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation. Int J Dev Biol. 2000;44(3):297–307
- . FGF signaling regulates mesoderm cell fate specification and morphogenetic movement at the primitive streak. Dev Cell. 2001;1(1):37–49
- . The early steps of neural crest development. Mech Dev. 2001;105(1-2):27–35
- . Epithelial-mesenchymal transformations in early avian heart development. Acta Anat (Basel). 1996;156(3):173–186
- . Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer. 2002;2(6):442–454
- . Embryonic transcription factors in human breast cancer. IUBMB Life. 2006;58(3):123–132
- E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines. Br J Cancer. 2006;94(5):661–671
- . Hypoxia-inducible factor-1alpha induces the epithelial-mesenchymal transition of human prostatecancer cells. Chin Med J (Engl). 2006;119(9):713–718
- Endothelin-1 promotes epithelial-to-mesenchymal transition in human ovarian cancer cells. Cancer Res. 2005;65(24):11649–11657
- . Tumor invasion in the absence of epithelial-mesenchymal transition: podoplanin-mediated remodeling of the actin cytoskeleton. Cancer Cell. 2006;9(4):261–272
- Epithelial versus mesenchymal phenotype determines in vitro sensitivity and predicts clinical activity of erlotinib in lung cancer patients. Clin Cancer Res. 2005;11(24 Pt 1):8686–8698
- . Host microenvironment in breast cancer development: epithelial-mesenchymal transition in breast cancer development. Breast Cancer Res. 2003;5(2):101–106
- Androgen-independent cancer progression and bone metastasis in the LNCaP model of human prostate cancer. Cancer Res. 1994;54(10):2577–2581
- . Secondary solid neoplasms of the prostate: a clinico-pathological series of 51 cases. Virchows Arch. 2002;440(4):392–396
- Suppression of prostate cancer induced bone remodeling by the endothelin receptor A antagonist atrasentan. J Urol. 2003;169(3):1143–1149
- . Zoledronic acid to prevent skeletal complications in cancer: corroborating the evidence. Cancer Treat Rev. 2005;31(suppl 3):19–25
- In vivo effects of the human type I insulin-like growth factor receptor antibody A12 on androgen-dependent and androgen-independent xenograft human prostate tumors. Clin Cancer Res. 2005;11(8):3065–3074
- . Antiangiogenesis: a possible treatment option for prostate cancer?. Clin Genitourin Cancer. 2005;4(3):197–202
- Bone-targeted therapy for advanced androgen-independent carcinoma of the prostate: a randomised phase II trial. Lancet. 2001;357(9253):336–341
- . Immunosurveillance against cancer and immunotherapy: synergy or antagonism?. N Engl J Med. 2003;348(3):252–254
- . Cancer immunoediting: from immunosurveillance to tumor escape. Nat Immunol. 2002;3(11):991–998
- Intratumoral T cells, recurrence, and survival in epithelial ovarian cancer. N Engl J Med. 2003;348(3):203–213
- . Human tumor antigens recognized by T lymphocytes. J Exp Med. 1996;183(3):725–729
- A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma. Science. 1991;254(5038):1643–1647
- . A listing of human tumor antigens recognized by T cells. Cancer Immunol Immunother. 2001;50(1):3–15
- Immunoselection in vivo: independent loss of MHC class I and melanocyte differentiation antigen expression in metastatic melanoma. Int J Cancer. 1997;71(2):142–147
- . Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance. Immunol Today. 1995;16(10):487–494
- Implications for immunosurveillance of altered HLA class I phenotypes in human tumours. Immunol Today. 1997;18(2):89–95
- . HLA class I antigen downregulation in human cancers: T-cell immunotherapy revives an old story. Mol Med Today. 1999;5(4):178–186
- . Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance. Adv Immunol. 2000;74:181–273
- Functional analysis of antigen-specific T lymphocytes by serial measurement of gene expression in peripheral blood mononuclear cells and tumor specimens. J Immunol. 1999;163(12):6867–6875
- Functional dissociation between local and systemic immune response during anti-melanoma peptide vaccination. J Immunol. 1998;161(8):4183–4194
- Expansion of tumor-T cell pairs from fine needle aspirates of melanoma metastases. J Immunol. 2000;164(1):495–504
- . Disregulation in TH1 and TH2 subsets of CD4+ T cells in peripheral blood of colorectal cancer patients and involvement in cancer establishment and progression. Cancer Immunol Immunother. 1996;42(1):1–8
- . Interleukin 2 restores CD3-zeta chain expression but fails to generate tumour-specific lytic activity in tumour-infiltrating lymphocytes derived from human colorectal hepatic metastases. Br J Cancer. 1998;77(7):1072–1081
- Characterization of circulating T cells specific for tumor-associated antigens in melanoma patients. Nat Med. 1999;5(6):677–685
- . Role of transforming growth factor beta in cancer. J Cell Physiol. 2001;186(2):153–168
- . Natural selection of tumor variants in the generation of “tumor escape” phenotypes. Nat Immunol. 2002;3(11):999–1005
- Regulation of the innate and adaptive immune responses by Stat-3 signaling in tumor cells. Nat Med. 2004;10(1):48–54
- Cancer immunotherapy with peptide-based vaccines: what have we achieved? Where are we going?. J Natl Cancer Inst. 2002;94(11):805–818
- . Natural T cell immunity against cancer. Clin Cancer Res. 2003;9(12):4296–4303
- Natural T-cell response against MHC class I epitopes of epithelial cell adhesion molecule, her-2/neu, and carcinoembryonic antigen in patients with colorectal cancer. Cancer Res. 2000;60(17):4850–4854
- Phenotypic and functional separation of memory and effector human CD8+ T cells. J Exp Med. 1997;186(9):1407–1418
- . Rational peptide-based tumour vaccine development and T cell monitoring. Semin Cancer Biol. 2003;13(6):423–429
- . Tumour-cell invasion and migration: diversity and escape mechanisms. Nat Rev Cancer. 2003;3(5):362–374
- . Matrix metalloproteinases in cancer: from new functions to improved inhibition strategies. Int J Dev Biol. 2004;48(5-6):411–424
- . Tumour microenvironment - opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nat Rev Cancer. 2006;6(3):227–239
- Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res. 2005;65(12):5278–5283
- . Chemokine biology in cancer. Semin Immunol. 2003;15(1):49–55
- . Properties and origin of osteoblasts. Clin Orthop Relat Res. 1990;252:276–293
- . Acellular mineral deposition in collagen-based biomaterials incubated in cell culture media. Calcif Tissue Int. 2000;66(3):204–211
- . Aspects of collagen mineralization in hard tissue formation. Int Rev Cytol. 2005;242:121–156
- Fibronectin regulates calvarial osteoblast differentiation. J Cell Sci. 1996;109(Pt 6):1369–1380
- Bone sialoprotein mediates human endothelial cell attachment and migration and promotes angiogenesis. Circ Res. 2000;86(8):885–891
- . Photoencapsulation of osteoblasts in injectable RGD-modified PEG hydrogels for bone tissue engineering. Biomaterials. 2002;23(22):4315–4323
- . Interactions of connective tissue cells with the extracellular matrix. Bone. 1995;17(2):51S–53S(suppl).
- . Bone cell matrix promotes the adhesion of human prostatic carcinoma cells via the alpha 2 beta 1 integrin. Clin Exp Metastasis. 1996;14(1):19–26
- . Osteopontin: a key cytokine in cell-mediated and granulomatous inflammation. Int J Exp Pathol. 2000;81(6):373–390
- . Osteoblast-like cell adhesion to bone sialoprotein peptides. J Orthop Res. 2004;22(2):353–361
- . Adhesion of osteosarcoma cells to the 70-kDa core region of thrombospondin-1 is mediated by the alpha 4 beta 1 integrin. Biochem Biophys Res Commun. 2002;293(1):86–92
- . Osteomimetic properties of prostate cancer cells: a hypothesis supporting the predilection of prostate cancer metastasis and growth in the bone environment. Prostate. 1999;39(4):246–261
- Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. Development. 1999;126(13):2911–2920
- . Growth factors regulate expression of osteoblast-associated genes. J Periodontol. 1999;70(11):1345–1354
- . Non-collagen proteins in bone. Ciba Found Symp. 1988;136:178–202
- Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol Cell. 2003;14(1):173–189
- Localization and possible role of two different alpha v beta 3 integrin conformations in resting and resorbing osteoclasts. J Cell Sci. 2002;115(Pt 14):2919–2929
- Regulation of osteoclast function and bone mass by RAGE. J Exp Med. 2006;203(4):1067–1080
- . Critical role of beta3 integrin in experimental postmenopausal osteoporosis. J Bone Miner Res. 2005;20(12):2116–2123
- Platelet and osteoclast beta3 integrins are critical for bone metastasis. Proc Natl Acad Sci U S A. 2003;100(24):14205–14210
- Proteolytic activity of human osteoclast cathepsin K (Expression, purification, activation, and substrate identification). J Biol Chem. 1996;271(21):12517–12524
- . Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B. J Clin Invest. 1995;95(5):2089–2095
- In vivo inhibition of osteoblastic metalloproteinases leads to increased trabecular bone mass. J Bone Miner Res. 2004;19(5):811–822
- . Stimulation of RANKL and inhibition of membrane-type matrix metalloproteinase-1 expression by parathyroid hormone in normal human osteoblasts. Endocr Res. 2004;30(3):369–377
- A crucial role for matrix metalloproteinase 2 in osteocytic canalicular formation and bone metabolism. J Biol Chem. 2006;281(44):33814–33824
- Matrix metalloproteinase activity, bone matrix turnover, and tumor cell proliferation in prostate cancer bone metastasis. J Natl Cancer Inst. 2002;94(1):17–25
- The inhibition of subchondral bone resorption in the early phase of experimental dog osteoarthritis by licofelone is associated with a reduction in the synthesis of MMP-13 and cathepsin K. Bone. 2004;34(3):527–538
- . Stromal cell-derived factor-1 (SDF-1) recruits osteoclast precursors by inducing chemotaxis, matrix metalloproteinase-9 (MMP-9) activity, and collagen transmigration. J Bone Miner Res. 2003;18(8):1404–1418
- Impaired bone resorption in cathepsin K-deficient mice is partially compensated for by enhanced osteoclastogenesis and increased expression of other proteases via an increased RANKL/OPG ratio. Bone. 2005;36(1):159–172
- . A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone. 2004;35(5):1107–1119
- . RANK ligand signaling modulates the matrix metalloproteinase-9 gene expression during osteoclast differentiation. Exp Cell Res. 2007;313(1):168–178
- . Effect of CD44 deficiency on in vitro and in vivo osteoclast formation. J Cell Biochem. 2005;94(5):954–966
- . Generation and activity of equine osteoclasts in vitro: effects of the bisphosphonate pamidronate (APD). Res Vet Sci. 2002;72(2):105–113
- . alphavbeta3 and macrophage colony-stimulating factor: partners in osteoclast biology. Immunol Rev. 2005;208:88–105
- . Parathyroid hormone controls receptor activator of NF-kappaB ligand gene expression via a distant transcriptional enhancer. Mol Cell Biol. 2006;26(17):6453–6468
- Imbalance of RANKL/RANK/OPG system in interface tissue in loosening of total hip replacement. J Bone Joint Surg Br. 2003;85(8):1196–1201
- Protein expression and functional difference of membrane-bound and soluble receptor activator of NF-kappaB ligand: modulation of the expression by osteotropic factors and cytokines. Biochem Biophys Res Commun. 2000;275(3):768–775
- . CpG oligodeoxynucleotides modulate the osteoclastogenic activity of osteoblasts via Toll-like receptor 9. J Biol Chem. 2003;278(19):16732–16740
- Genetic evidence for a role for Src family kinases in TNF family receptor signaling and cell survival. Genes Dev. 2001;15(2):241–253
- OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis. Nature. 1999;397(6717):315–323
- . Osteoprotegerin secretion from prostate cancer is stimulated by cytokines (in vitro). Biochem Biophys Res Commun. 2002;293(1):451–455
- . Soluble receptor activator of nuclear factor kappaB Fc diminishes prostate cancer progression in bone. Cancer Res. 2003;63(22):7883–7890
- Severe osteoporosis in mice lacking osteoclastogenesis inhibitory factor/osteoprotegerin. Biochem Biophys Res Commun. 1998;247(3):610–615
- osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev. 1998;12(9):1260–1268
- . Bone metastases: the clinical problem. Eur J Cancer. 1998;34(2):210–213
- . Pathophysiologic interactions in skeletal metastasis. Cancer. 2000;88(12):2912–2918(suppl).
- . Mechanisms of bone metastasis. N Engl J Med. 2004;350(16):1655–1664
- . Tumor-derived platelet-derived growth factor-BB plays a critical role in osteosclerotic bone metastasis in an animal model of human breast cancer. Cancer Res. 2002;62(3):917–923
- . Slit protein-mediated inhibition of CXCR4-induced chemotactic and chemoinvasive signaling pathways in breast cancer cells. J Biol Chem. 2004;279(10):9115–9124
- . Is cancer a disease of self-seeding?. Nat Med. 2006;12(8):875–878
- Stromal factors involved in prostate carcinoma metastasis to bone. Cancer. 2003;97(3):739–747(suppl).
- . Extracellular matrix alterations in conventional renal cell carcinomas by tissue microarray profiling influenced by the persistent, long-term, low-dose ionizing radiation exposure in humans. Virchows Arch. 2006;448(5):584–590
- . Prostate cancer bone metastases promote both osteolytic and osteoblastic activity. J Cell Biochem. 2004;91(4):718–729
- Regulation of human osteocalcin promoter in hormone-independent human prostate cancer cells. J Biol Chem. 2002;277(4):2468–2476
- . Collagenase 3 is a target of Cbfa1, a transcription factor of the runt gene family involved in bone formation. Mol Cell Biol. 1999;19(6):4431–4442
- . Markers of bone turnover for the management of patients with bone metastases from prostate cancer. Br J Cancer. 2000;82(4):858–864
- Bone turnover mediates preferential localization of prostate cancer in the skeleton. Endocrinology. 2005;146(4):1727–1736
- . Metabolic bone disease induced by prostate cancer: rationale for the use of bisphosphonates. J Urol. 2001;166(6):2023–2031
- . The role of bisphosphonates in men with prostate cancer receiving androgen deprivation therapy. Oncology (Williston Park). 2004;18(5):21–25(suppl 3).
- . Molecular mechanisms of tumor-bone interactions in osteolytic metastases. Crit Rev Eukaryot Gene Expr. 2000;10(2):159–178
- . Metastasis: Metastasis to bone: causes, consequences and therapeutic opportunities. Nat Rev Cancer. 2002;2(8):584–593
- . Humanized monoclonal antibody against parathyroid hormone-related protein suppresses osteolytic bone metastasis of human breast cancer cells derived from MDA-MB-231. Anticancer Res. 2005;25(6B):3817–3823
- Osteoprotegerin inhibits prostate cancer-induced osteoclastogenesis and prevents prostate tumor growth in the bone. J Clin Invest. 2001;107(10):1235–1244
- . The effect of bone-associated growth factors and cytokines on the growth of prostate cancer cells derived from soft tissue versus bone metastases in vitro. Int J Oncol. 2003;22(4):921–926
- . Use of the stromal cell-derived factor-1/CXCR4 pathway in prostate cancer metastasis to bone. Cancer Res. 2002;62(6):1832–1837
- Pain and its treatment in outpatients with metastatic cancer. N Engl J Med. 1994;330(9):592–596
- . Cancer gene therapy: an awkward adolescence. Cancer Gene Ther. 2003;10(7):501–508
- . MAPK pathways in radiation responses. Oncogene. 2003;22(37):5885–5896
- A sense of danger from radiation. Radiat Res. 2004;162(1):1–19
- Basic fibroblast growth factor protects endothelial cells against radiation-induced programmed cell death in vitro and in vivo. Cancer Res. 1994;54(10):2582–2590
- . Transforming growth factor-beta 1 expression in irradiated liver. Radiat Res. 1990;122(1):77–85
- . Transforming growth factor-beta activation in irradiated murine mammary gland. J Clin Invest. 1994;93(2):892–899
- . Cellular sources of transforming growth factor-beta isoforms in early and chronic radiation enteropathy. Am J Pathol. 1998;153(5):1531–1540
- . Conversion of a high molecular weight latent beta-TGF from chicken embryo fibroblasts into a low molecular weight active beta-TGF under acidic conditions. Biochem Biophys Res Commun. 1985;133(3):1026–1034
- . Redox-mediated activation of latent transforming growth factor-beta 1. Mol Endocrinol. 1996;10(9):1077–1083
- TGF-beta signaling in fibroblasts modulates the oncogenic potential of adjacent epithelia. Science. 2004;303(5659):848–851
- Transforming growth factor-beta1 mediates cellular response to DNA damage in situ. Cancer Res. 2002;62(20):5627–5631
- . Gut instincts: thoughts on intestinal epithelial stem cells. J Clin Invest. 2000;105(11):1493–1499
- . Differential expression of transforming growth factors alpha and beta in rat intestinal epithelial cells. J Clin Invest. 1989;83(5):1768–1773
- . Regulation of intestinal epithelial cell growth by transforming growth factor type beta. Proc Natl Acad Sci U S A. 1989;86(5):1578–1582
- . Pretreatment with transforming growth factor beta-3 protects small intestinal stem cells against radiation damage in vivo. Br J Cancer. 1997;75(10):1454–1459
- Interference with transforming growth factor-beta/ Smad3 signaling results in accelerated healing of wounds in previously irradiated skin. Am J Pathol. 2003;163(6):2247–2257
- Soluble TGFbeta type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. Int J Radiat Oncol Biol Phys. 2003;57(2):563–572
- Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem. 2004;279(15):15167–15176
- . How do tissues respond to damage at the cellular level? (The role of cytokines in irradiated tissues). Radiat Res. 1998;150(5):S109–S120(suppl).
- . What is cancer chemotherapy?. Acta Oncol. 2001;40(2-3):166–174
- . Structure and function of efflux pumps that confer resistance to drugs. Biochem J. 2003;376(Pt 2):313–338
- . Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2002;2(1):48–58
- . ATP binding cassette transporters and drug resistance in breast cancer. Endocr Relat Cancer. 2003;10(1):43–73
- . From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol Life Sci. 2001;58(7):931–959
- . Cancer multidrug resistance. Nat Biotechnol. 1999;17(1):94–95
- . P glycoprotein and the mechanism of multidrug resistance. Novartis Found Symp. 2002;243:54–65
- . The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 1995;30(6):445–600
- . The role of glutathione-S-transferase in anti-cancer drug resistance. Oncogene. 2003;22(47):7369–7375
- . Clinical resistance to topoisomerase-targeted drugs. Biochim Biophys Acta. 1998;1400(1-3):275–288
- . Microtubule alterations and resistance to tubulin-binding agents (review). Int J Oncol. 2002;21(3):621–628
- . Mechanisms of Taxol resistance related to microtubules. Oncogene. 2003;22(47):7280–7295
- . Mechanisms of resistance to topoisomerase I-targeting drugs. Oncogene. 2003;22(47):7296–7304
- . Taxol resistance. Chemotherapy. 2000;46(5):327–334
- . Overcoming resistance of cancer cells to apoptosis. J Cell Physiol. 2003;196(1):9–18
- . Bcl-2: prevention of apoptosis as a mechanism of drug resistance. Hematol Oncol Clin North Am. 1995;9(2):451–473
- . Drug resistance and apoptosis in cancer treatment: development of new apoptosis-inducing agents active in drug resistant malignancies. Curr Med Chem Anticancer Agents. 2002;2(3):387–401
- . Overview of the clinical efficacy of investigational anticancer drugs. J Intern Med. 2003;253(1):46–75
- Tumor resistance to alkylating agents conferred by mechanisms operative only in vivo. Science. 1990;247(4949 Pt 1):1457–1461
- . Orthotopic metastatic mouse models for anticancer drug discovery and evaluation: a bridge to the clinic. Invest New Drugs. 1999;17(4):343–359
- . Vascular endothelial growth factor (VEGF)-C signaling through FLT-4 (VEGFR-3) mediates leukemic cell proliferation, survival, and resistance to chemotherapy. Blood. 2002;99(6):2179–2184
- . Hematopoietic cytokines inhibit apoptosis induced by transforming growth factor beta 1 and cancer chemotherapy compounds in myeloid leukemic cells. Blood. 1992;80(7):1750–1757
- . Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: reversal by decorin. In Vivo. 1997;11(6):463–472
- . Nitric oxide upregulates expression of DNA-PKcs to protect cells from DNA-damaging anti-tumour agents. Nat Cell Biol. 2000;2(6):339–345
- . The role of IL-6 and STAT3 in inflammation and cancer. Eur J Cancer. 2005;41(16):2502–2512
- The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway. Oncogene. 2001;20(41):5799–5809
- Interleukin-6 inhibits Fas-induced apoptosis and stress-activated protein kinase activation in multiple myeloma cells. Blood. 1997;89(1):227–234
- . Interleukin-6 inhibits apoptosis of malignant plasma cells. Cell Immunol. 1995;162(2):248–255
- . The Fas death factor. Science. 1995;267(5203):1449–1456
- Autocrine generation and requirement of BSF-2/IL-6 for human multiple myelomas. Nature. 1988;332(6159):83–85
- . Interleukin-6 in human multiple myeloma. Blood. 1995;85(4):863–872
- Interleukin-6 prevents dexamethasone-induced myeloma cell death. Blood. 1994;84(9):3063–3070
- Myeloma cell growth arrest, apoptosis, and interleukin-6 receptor modulation induced by EB1089, a vitamin D3 derivative, alone or in association with dexamethasone. Blood. 1996;88(12):4659–4666
- . Dexamethasone and suramin inhibit cell proliferation and interleukin-6-mediated immunoglobulin secretion in human lymphoid and multiple myeloma cell lines. Leuk Lymphoma. 1995;17(5-6):485–494
- IL-6-induced homodimerization of gp130 and associated activation of a tyrosine kinase. Science. 1993;260(5115):1808–1810
- . Interleukin-6 family of cytokines and gp130. Blood. 1995;86(4):1243–1254
- Association of transcription factor APRF and protein kinase Jak1 with the interleukin-6 signal transducer gp130. Science. 1994;263(5143):89–92
- . Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science. 1994;264(5164):1415–1421
- . STATs: signal transducers and activators of transcription. Cell. 1996;84(3):331–334
- BCL-X expression in multiple myeloma: possible indicator of chemoresistance. Cancer Res. 1998;58(2):256–262
- . Prevention of myeloma cell apoptosis by ectopic bcl-2 expression or interleukin 6-mediated up-regulation of bcl-xL. Cancer Res. 1995;55(11):2262–2265
- . Effects of intercellular contact on repair of radiation damage. Exp Cell Res. 1972;71(1):75–80
- Impact of the cyclin-dependent kinase inhibitor p27Kip1 on resistance of tumor cells to anticancer agents. Nat Med. 1996;2(11):1204–1210
- . Integrins as novel drug targets for overcoming innate drug resistance. Curr Cancer Drug Targets. 2002;2(1):37–43
- . Integrin-mediated drug resistance in multiple myeloma. Leuk Lymphoma. 2000;38(1-2):71–81
- Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor. Haematologica. 2005;90(4):479–488
- . Cell adhesion-mediated drug resistance (CAM-DR) protects the K562 chronic myelogenous leukemia cell line from apoptosis induced by BCR/ABL inhibition, cytotoxic drugs, and gamma-irradiation. Leukemia. 2001;15(8):1232–1239
- Reduction in drug-induced DNA double-strand breaks associated with beta1 integrin-mediated adhesion correlates with drug resistance in U937 cells. Blood. 2001;98(6):1897–1903
- Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: a mechanism for small cell lung cancer growth and drug resistance in vivo. Nat Med. 1999;5(6):662–668
- beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. Cancer Cell. 2002;2(3):205–216
- . TNF- and cancer therapy-induced apoptosis: potentiation by inhibition of NF-kappaB. Science. 1996;274(5288):784–787
- . Cell adhesion-mediated drug resistance (CAM-DR) is associated with activation of NF-kappa B (RelB/p50) in myeloma cells. Oncogene. 2003;22(16):2417–2421
- . Cell-adhesion-dependent influences on genomic instability and carcinogenesis. Curr Opin Cell Biol. 1998;10(5):647–653
- . New prospectives of prostate cancer gene therapy: molecular targets and animal models. Crit Rev Eukaryot Gene Expr. 2001;11(1-3):77–120
- A novel targeting modality to enhance adenoviral replication by vitamin D(3) in androgen-independent human prostate cancer cells and tumors. Cancer Res. 2002;62(11):3084–3092
- A conditional replication-competent adenoviral vector, Ad-OC-E1a, to cotarget prostate cancer and bone stroma in an experimental model of androgen-independent prostate cancer bone metastasis. Cancer Res. 2001;61(16):6012–6019
- . The distribution of secondary growths in cancer of the breast (1889). Cancer Metastasis Rev. 1889;8(2):98–101
- Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors. Proc Natl Acad Sci U S A. 2002;99(4):2246–2251
Dr. Chung is a Georgia Cancer Coalition Distinguished Cancer Scholar, supported in part by the Georgia Cancer Coalition, NCI Grant 1PO1CA098912-01 and DOD Grant DAMD 17-03-2-0033. Dr. Johnstone is a Georgia Cancer Coalition Distinguished Cancer Scholar, supported in part by the Georgia Cancer Coalition and NCMHD Grant 5P60-MD-000525.
PII: S0147-0272(06)00076-6
doi: 10.1016/j.currproblcancer.2006.12.002
© 2007 Elsevier Inc. All rights reserved.
« Previous
Current Problems in Cancer
Volume 31, Issue 2
, Pages 36-100
, March 2007
