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Current Problems in Cancer
Volume 30, Issue 3
, Pages 107-158
, May 2006
Hodgkin’s Lymphoma
References
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American Cancer Society. Cancer facts and figures, 2006. Available from: http://www.cancer.org/docroot/stt/stt0.asp.
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Was the bimodal age incidence of Hoddgkin’s Lymphoma a result of mistaken diagnoses of non-Hodgkin’s Lymphoma?
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- Low-dose radiation is sufficient for the noninvolved extended-field treatment in favorable early-stage Hodgkin’s disease (long-term results of a randomized trial of radiotherapy alone) . J Clin Oncol . 2001;19:2905–2914
- Involved-field radiotherapy is equally effective and less toxic compared with extended-field radiotherapy after four cycles of chemotherapy in patients with early-stage unfavorable Hodgkin’s lymphoma (results of the HD8 trial of the German Hodgkin’s Lymphoma Study Group) . J Clin Oncol . 2003;21:3601–3608
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.
Transformation in the use of radiation therapy of Hodgkin lymphoma
(new concepts and indications lead to modern field design and are assisted by PET imaging and intensity modulated radiation therapy (IMRT))
.
Eur J Haematol
. 2005;(Suppl):90–97
- Comparison of 30 Gy versus 20 Gy involved field radiotherapy after two versus four cycles of ABVD in early stage Hodgkin’s Lymphoma (Interim analysis of the German Hodgkin Study Group Trial HD10) . Int J Radiat Oncol Biol Phys . 2005;63(suppl 1):S1
- Combined-modality therapy versus radiotherapy alone for treatment of early-stage Hodgkin’s disease (cure balanced against complications) . J Clin Oncol . 2006;24:605–611
- Centralized radiation oncologic review of cross-sectional imaging of Hodgkin’s disease leads to significant changes in required involved field-results of a quality assurance program of the German Hodgkin Study Group . Int J Radiat Oncol Biol Phys . 2004;58:1121–1127
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- Long-term results of a randomised trial of involved field radiotherapy vs extended field radiotherapy in stage I and II Hodgkin lymphoma . Clin Oncol (R Coll Radiol) . 2005;17:47–53
- Long-term survival and competing causes of death in patients with early-stage Hodgkin’s disease treated at age 50 or younger . J Clin Oncol . 2002;20:2101–2108
- Mantle irradiation alone for clinical stage I-II Hodgkin’s disease (long-term follow-up and analysis of prognostic factors in 261 patients) . J Clin Oncol . 1999;17:230–240
- Results of a prospective trial of mantle irradiation alone for selected patients with early-stage Hodgkin’s disease . J Clin Oncol . 2001;19:736–741
- Mantle irradiation alone for pathologic stage I and II Hodgkin’s disease (long-term follow-up and patterns of failure) . Int J Radiat Oncol Biol Phys . 2001;50:971–977
- . Influence of more extensive radiotherapy and adjuvant chemotherapy on long-term outcome of early-stage Hodgkin’s disease (a meta-analysis of 23 randomized trials involving 3,888 patients) . J Clin Oncol . 1998;16:830–843
- BEACOPP and COPP/ABVD as salvage treatment after primary extended field radiation therapy of early stage Hodgkins disease (results of the German Hodgkin Study Group) . Leuk Lymphoma . 2005;46:1561–1567
- Phase III randomized intergroup trial of subtotal lymphoid irradiation versus doxorubicin, vinblastine, and subtotal lymphoid irradiation for stage IA to IIA Hodgkin’s disease . J Clin Oncol . 2001;19:4238–4244
- . Very long-term follow-up of the Danish National Hodgkin Study Group’s randomized trial of radiotherapy (RT) alone vs. combined modality treatment (CMT) for early stage Hodgkin Lymphoma, with special reference to second tumours and overall survival . Blood . 2003;102:2351
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Three cycles of MOPP/ABV hybrid and involved-field irradiation is more effective than subtotal nodal irradiation in favourable supradiagpragmatic clinical stages I-II Hodgkin’s lymphoma
(preliminary results of the EORTC-GELA H8-F randomized trial (#20931) in 543 patients)
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Leuk Lymphoma
. 2001;42:12
- ABVD plus subtotal nodal versus involved-field radiotherapy in early-stage Hodgkin’s disease (long-term results) . J Clin Oncol . 2004;22:2835–2841
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Brief Chemotherapy (CT) with involved field (IFRT) or extended field (EFRT) radiation after clinical staging (CS) are equivalent and both superior to EFRT alone following laparotomy staging (PS IA, IIA) in limited Hodgkin’s lymphoma (HL)
.
Leuk Lymphoma
. 2001;42(S2):51;
Abstract p-087
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Minimal initial chemotherapy plus involved field radiotherapy (RT) vs. mnatle field RT for clinical IA/IIA supra-diaphragmatic Hodgkin’s disease (HD)
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Eur J Haematol
. 2004;73(suppl 65):39
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- The achievements of the EORTC Lymphoma Group. European Organisation for Research and Treatment of Cancer . Eur J Cancer . 2002;38(suppl 4):S107–S113
- Chemotherapy of advanced Hodgkin’s disease with MOPP, ABVD, or MOPP alternating with ABVD . N Engl J Med . 1992;327:1478–1484
- Randomized comparison of ABVD and MOPP/ABV hybrid for the treatment of advanced Hodgkin’s disease (report of an intergroup trial) . J Clin Oncol . 2003;21:607–614
- . Radiation therapy in Hodgkin disease (why risk a Pyrrhic victory?) . J Natl Cancer Inst . 2005;97:1394–1395
- . Chemotherapy alone for early Hodgkin’s lymphoma (an emerging option) . J Clin Oncol . 2005;23:4574–4576
- Radiation therapy versus combination chemotherapy in the treatment of early-stage Hodgkin’s disease (seven-year results of a prospective randomized trial) . J Clin Oncol . 1991;9:906–917
- Extended-field radiotherapy is superior to MOPP chemotherapy for the treatment of pathologic stage I-IIA Hodgkin’s disease (eight-year update of an Italian prospective randomized study) . J Clin Oncol . 1992;10:378–382
- Randomized trial of chemotherapy versus chemotherapy plus radiotherapy for stage I-II Hodgkin’s disease . J Natl Cancer Inst . 1988;80:1466–1473
- Randomized comparison of low-dose involved-field radiotherapy and no radiotherapy for children with Hodgkin’s disease who achieve a complete response to chemotherapy . J Clin Oncol . 2002;20:3765–3771
- Randomized comparison of ABVD chemotherapy with a strategy that includes radiation therapy in patients with limited-stage Hodgkin’s lymphoma (National Cancer Institute of Canada Clinical Trials Group and the Eastern Cooperative Oncology Group) . J Clin Oncol . 2005;23:4634–4642
- Results of a prospective randomized clinical trial of doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD) followed by radiation therapy (RT) versus ABVD alone for stages I, II, and IIIA nonbulky Hodgkin disease . Blood . 2004;104:3483–3489
- Pericarditis and myocardial infarction after Hodgkin’s disease therapy . Int J Radiat Oncol Biol Phys . 1991;21:447–449
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MOPP/ABV hybrid and irradiation in unfavourable supradiaphragmatic clinical stages I-II Hodgkin’s lymphoma
(preliminary results of the EORTC-GELA H8-U randomized trial (# 20931) in 995 patients)
.
Leuk Lymphoma
. 2001;42:12
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Intensification of chemotherapy and concomitant reduction of radiotherapy dose in intermediate stage Hodgkin’s lymphoma
(results of the fourth interim analysis of the HD 11 trial of the GHSG)
.
Eur J Haematol
. 2004;73(suppl 65):37
- ABVD versus modified stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate- and advanced-stage Hodgkin’s lymphoma (final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi) . J Clin Oncol . 2005;23:9198–9207
- . Long-term follow-up of Hodgkin’s disease trial . N Engl J Med . 2002;346:1417–1418
- Treatment of advanced Hodgkin’s disease with chemotherapy–comparison of MOPP/ABV hybrid regimen with alternating courses of MOPP and ABVD (a report from the National Cancer Institute of Canada clinical trials group) . J Clin Oncol . 1997;15:1638–1645
- ChlVPP alternating with PABlOE is superior to PABlOE alone in the initial treatment of advanced Hodgkin’s disease (results of a British National Lymphoma Investigation/Central Lymphoma Group randomized controlled trial) . Br J Cancer . 2001;84:1293–1300
- Comparison of ABVD and alternating or hybrid multidrug regimens for the treatment of advanced Hodgkin’s lymphoma (results of the United Kingdom Lymphoma Group LY09 Trial (ISRCTN97144519)) . J Clin Oncol . 2005;23:9208–9218
- Standard and increased-dose BEACOPP chemotherapy compared with COPP-ABVD for advanced Hodgkin’s disease . N Engl J Med . 2003;348:2386–2395
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Results of the third interim analysis of the HD12 trial of the GHSG
(eight courses of escalated BEACOPP versus 4 escalated and 4 baseline courses of BEACOPP with or without additive radiotherapy for advanced stage Hodgkin s Lymphoma)
.
Blood
. 2003;102:85
- Prognostic factors among 185 adults with newly diagnosed advanced Hodgkin’s disease treated with alternating potentially noncross-resistant chemotherapy and intermediate-dose radiation therapy . J Clin Oncol . 1990;8:1173–1186
- High-dose therapy and autologous stem-cell transplantation versus conventional therapy for patients with advanced Hodgkin’s lymphoma responding to front-line therapy . J Clin Oncol . 2003;21:2320–2325
- Hodgkin’s lymphoma in elderly patients (a comprehensive retrospective analysis from the German Hodgkin’s Study Group) . J Clin Oncol . 2005;23:5052–5060
- A prospectively randomized trial carried out by the German Hodgkin Study Group (GHSG) for elderly patients with advanced Hodgkin’s disease comparing BEACOPP baseline and COPP-ABVD (study HD9elderly) . Ann Oncol . 2005;16:124–131
- Involved-field radiotherapy for advanced Hodgkin’s lymphoma . N Engl J Med . 2003;348:2396–2406
- Meta-analysis of chemotherapy versus combined modality treatment trials in Hodgkin’s disease . J Clin Oncol . 1998;16:818–829
- Consolidation radiation after complete remission in Hodgkin’s disease following six cycles of doxorubicin, bleomycin, vinblastine, and dacarbazine chemotherapy (is there a need?) . J Clin Oncol . 2004;22:62–68
- . Chemotherapy or combined modality treatment (the optimal treatment for Hodgkin’s disease) . J Clin Oncol . 2004;22:15–18
- Comparison of chemotherapy to radiotherapy as consolidation of complete or good partial response after six cycles of chemotherapy for patients with advanced Hodgkin’s disease (results of the groupe d’etudes des lymphomes de l’Adulte H89 trial) . Blood . 2000;95:2246–2252
- Advanced Hodgkin disease with large mediastinal involvement can be treated with eight cycles of chemotherapy alone after a major response to six cycles of chemotherapy (a study of 82 patients from the Groupes d’Etudes des Lymphomes de l’Adulte H89 trial) . Cancer . 2001;92:453–459
- Low-dose involved field radiation after chemotherapy in advanced Hodgkin disease. A Southwest Oncology Group randomized study . Ann Intern Med . 1994;120:903–912
- Assessment of the Stanford V regimen and consolidative radiotherapy for bulky and advanced Hodgkin’s disease (Eastern Cooperative Oncology Group Pilot Study E1492) . J Clin Oncol . 2000;18:972–980
- New prognostic score based on treatment outcome of patients with relapsed Hodgkin’s lymphoma registered in the database of the German Hodgkin’s lymphoma study group . J Clin Oncol . 2002;20:221–230
- . Prognostic factors and treatment outcome in primary progressive Hodgkin lymphoma (a report from the German Hodgkin Lymphoma Study Group) . Blood . 2000;96:1280–1286
- Autotransplantation for relapsed or refractory Hodgkin’s disease (long-term follow-up and analysis of prognostic factors) . Bone Marrow Transplant . 1998;22:265–271
- High-dose Etoposide and Melphalan, and autologous bone marrow transplantation for patients with advanced Hodgkin’s disease (Importance of disease status at transplant) . J Clin Oncol . 1993;11:704–711
- . Effectiveness of high dose chemoradiotherapy and autologous stem cell transplantation for patients with biopsy-proven primary refractory Hodgkin’s disease . Br J Haematol . 2004;124:645–652
- Autotransplants for Hodgkin’s disease in patients never achieving remission (a report from the Autologous Blood and Marrow Transplant Registry) . J Clin Oncol . 1999;17:534–545
- Autologous stem cell transplantation for primary refractory Hodgkin’s disease (results and clinical variables affecting outcome) . Ann Oncol . 2003;14:745–751
- Outcome of patients with Hodgkin’s disease failing after primary MOPP-ABVD . J Clin Oncol . 1997;15:528–534
- Comparison of high-dose therapy and autologous stem-cell transplantation with conventional therapy for Hodgkin’s disease induction failure (a case-control study) . J Clin Oncol . 1999;17:222–229
- Dose intensification with autologous bone-marrow transplantation in relapsed and resistant Hodgkin’s disease (results of a BNLI randomised trial) . Lancet . 1993;341:1051–1054
- Aggressive conventional chemotherapy compared with high-dose chemotherapy with autologous haemopoietic stem-cell transplantation for relapsed chemosensitive Hodgkin’s disease (a randomised trial) . Lancet . 2002;359:2065–2071
- Prognostic factors affecting long-term outcome after stem cell transplantation in Hodgkin’s lymphoma autografted after a first relapse . Ann Oncol . 2005;16:625–633
- A 2-step comprehensive high-dose chemoradiotherapy second-line program for relapsed and refractory Hodgkin disease (analysis by intent to treat and development of a prognostic model) . Blood . 2001;97:616–623
- Time-intensified dexamethasone/cisplatin/cytarabine (an effective salvage therapy with low toxicity in patients with relapsed and refractory Hodgkin’s disease) . Ann Oncol . 2002;13:1628–1635
- Cologne high-dose sequential chemotherapy in relapsed and refractory Hodgkin lymphoma (results of a large multicenter study of the German Hodgkin Lymphoma Study Group (GHSG)) . Ann Oncol . 2005;16:116–123
- Gemcitabine in the treatment of refractory Hodgkin’s disease (results of a multicenter phase II study) . J Clin Oncol . 2000;18:2615–2619
- Value of gemcitabine treatment in heavily pretreated Hodgkin’s disease patients . Haematologica . 2000;85:926–929
- . Synergistic interaction between cisplatin and gemcitabine in vitro . Clin Cancer Res . 1996;2:521–530
- Gemcitabine, dexamethasone and cisplatin is an active and non-toxic chemotherapy regimen in relapsed or refractory Hodgkin’s disease (a phase II study by the National Cancer Institute of Canada Clinical Trials Group) . Ann Oncol . 2003;14:1762–1767
- . Similar response rates and superior early progression-free survival with gemcitabine, dexamethasone, and cisplatin salvage therapy compared with carmustine, etoposide, cytarabine, and melphalan salvage therapy prior to autologous stem cell transplantation for recurrent or refractory Hodgkin lymphoma . Cancer . 2006;106:353–360
- . Patterns of failure following high-dose chemotherapy and autologous bone marrow transplantation with involved field radiotherapy for relapsed/refractory Hodgkin’s disease . Int J Radiat Oncol Biol Phys . 1995;33:261–270
- . Radical radiotherapy as salvage treatment for relapse of Hodgkin’s disease initially treated by chemotherapy alone (prognostic significance of the disease-free interval) . Int J Radiat Oncol Biol Phys . 1994;30:965–970
- . Salvage radiotherapy for Hodgkin’s disease following chemotherapy failure . Int J Radiat Oncol Biol Phys . 1997;39:599–607
- Salvage radiotherapy in patients with relapsed and refractory Hodgkin’s lymphoma (a retrospective analysis from the German Hodgkin Lymphoma Study Group) . J Clin Oncol . 2005;23:1522–1529
- . Long-term follow-up of salvage radiotherapy in Hodgkin’s lymphoma after chemotherapy failure . Int J Radiat Oncol Biol Phys . 2005;63:1538–1545
- . Salvage radiotherapy following chemotherapy failure in Hodgkin’s disease (what is its role?) . Acta Oncol . 1995;34:99–104
- . Integrating radiotherapy into bone marrow transplantation programs for Hodgkin’s disease . Int J Radiat Oncol Biol Phys . 1995;33:525–528
- Accelerated hyperfractionated total-lymphoid irradiation, high-dose chemotherapy, and autologous bone marrow transplantation for refractory and relapsing patients with Hodgkin’s disease . J Clin Oncol . 1993;11:1062–1070
- . Thoracic radiation therapy before autologous bone marrow transplantation in relapsed or refractory Hodgkin’s disease . Eur J Cancer . 1999;35:73–78
- . High-dose therapy and autologous bone marrow transplantation for relapsed/refractory Hodgkin’s disease (The impact of involved field radiotherapy on patterns of failure and survival) . Int J Radiat Oncol Biol Phys . 1996;36:3–12
- Autotransplantation for advanced lymphoma and Hodgkin’s disease followed by post-transplant rituxan/GM-CSF or radiotherapy and consolidation chemotherapy . Bone Marrow Transplant . 2002;29:303–312
- Phase I study of involved-field radiotherapy preceding autologous stem cell transplantation for patients with high-risk lymphoma or Hodgkin’s disease . Int J Radiat Oncol Biol Phys . 2004;59:208–218
- . Should involved-field radiation therapy be used as an adjunct to lymphoma autotransplantation? . Bone Marrow Transplant . 2002;29:183–189
- Optimal scheduling to reduce morbidity of involved field radiotherapy with transplantation for lymphomas (a prospective Australasian Leukaemia and Lymphoma Group Study) . Bone Marrow Transplant . 2005;35:291–298
- Progressive disease after ABMT for Hodgkin’s disease . Bone Marrow Transplant . 1997;20:761–765
- . What is the optimal treatment volume in Hodgkin’s disease patients undergoing high-dose chemotherapy and adjuvant radiation therapy? . Radiat Oncol Investig . 1999;7:353–359
- Evolution of treatment for Hodgkin’s disease (a population-based study of radiation therapy use and outcome) . Clin Oncol (R Coll Radiol) . 2003;15:255–263
- . Long-term cause-specific mortality of patients treated for Hodgkin’s disease . J Clin Oncol . 2003;21:3431–3439
- Cumulative absolute breast cancer risk for young women treated for Hodgkin lymphoma . J Natl Cancer Inst . 2005;97:1428–1437
- Lung cancer following chemotherapy and radiotherapy for Hodgkin’s disease . J Natl Cancer Inst . 2002;94:182–192
- Cardiac risk after mediastinal irradiation for Hodgkin’s disease . Radiother Oncol . 1998;46:51–62
- . Coronary artery disease mortality in patients treated for Hodgkin’s disease . Cancer . 1992;69:1241–1247
- . Long-term complications of treatment and causes of mortality after Hodgkin’s disease . Semin Radiat Oncol . 1996;6:225–242
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Factors affecting late mortality from heart disease after treatment of Hodgkin’s disease
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J Am Med Assoc
. 1993;270:1949–1955
- Symptomatic coronary artery disease after mantle irradiation for Hodgkin’s disease . Int J Radiat Oncol Biol Phys . 1996;36:881–889
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Valvular dysfunction and carotid, subclavian, and coronary artery disease in survivors of hodgkin lymphoma treated with radiation therapy
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J Am Med Assoc
. 2003;290:2831–2837
- Analysis of in-field control and late toxicity for adults with early-stage Hodgkin’s disease treated with chemotherapy followed by radiotherapy . Int J Radiat Oncol Biol Phys . 2003;55:36–43
- . Ischemic heart disease after mantlefield irradiation for Hodgkin’s disease in long-term follow-up . Radiother Oncol . 1999;51:35–42
- . Asymptomatic cardiac disease following mediastinal irradiation . J Am Coll Cardiol . 2003;42:743–749
- Cardiovascular status in long-term survivors of Hodgkin’s disease treated with chest radiotherapy . J Clin Oncol . 2004;22:3139–3148
- Cardiac injury as late toxicity of mediastinal radiation therapy for Hodgkin’s disease patients . Haematologica . 1996;81:132–137
- . Gonadal function following ABVD therapy for Hodgkin’s disease . Am J Clin Oncol . 1997;20:354–357
- . Gonadal damage in Hodgkin’s disease from cancer chemotherapeutic regimens . Arch Toxicol Suppl . 1984;7:140–145
- Secondary amenorrhea after Hodgkin’s lymphoma is influenced by age at treatment, stage of disease, chemotherapy regimen, and the use of oral contraceptives during therapy (a report from the German Hodgkin’s Lymphoma Study Group) . J Clin Oncol . 2005;23:7555–7564
- Comparison of psychosocial adaptation and sexual function of survivors of advanced Hodgkin disease treated by MOPP, ABVD, or MOPP alternating with ABVD . Cancer . 1992;70:2508–2516
- Hodgkin disease survivors at increased risk for problems in psychosocial adaptation . Cancer . 1992;70:2214–2224
- Late psychosocial sequelae in Hodgkin’s disease survivors (a French population-based case-control study) . J Clin Oncol . 1996;14:2444–2453
- . Reduced health-related quality of life among Hodgkin’s disease survivors (a comparative study with general population norms) . Ann Oncol . 1999;10:71–77
- Retrospective assessment of quality of life and treatment outcome in patients with Hodgkin’s disease from 1969 to 1994 . Eur J Cancer . 1999;35:698–706
- . Exercise reduces fatigue in chronic fatigued Hodgkins disease survivors (results from a pilot study) . Eur J Cancer . 2003;39:57–63
- Report of an international workshop to standardize response criteria for non-Hodgkin’s lymphomas . J Clin Oncol . 1999;17:1244–1253
- . Positron emission tomography imaging for lymphoma . Curr Opin Oncol . 2005;17:441–445
- . FDG PET in the evaluation of treatment for lymphoma (clinical usefulness and pitfalls) . Radiographics . 2005;25:191–207
- 18F-FDG PET early after radiotherapy in lymphoma patients . Cancer Biother Radiopharm . 2004;19:606–612
- (18)FDG-positron emission tomography in post treatment evaluation of residual mass in Hodgkin’s lymphoma (Long-term results) . Oncol Rep . 2005;14:1209–1214
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National Comprehensive Cancer Network (NCCN). The NCCN Clinical Practice Guidelines in Oncology. Hodgkin’s Disease. 2004. Available from: http://www.nccn.org.
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Follow up policy after treatment for Hodgkin’s disease
(too many clinic visits and routine tests? A review of hospital records)
.
Br Med J
. 1997;314:343–346
- . Detection of relapse in early-stage Hodgkin’s disease (role of routine follow-up studies) . J Clin Oncol . 1997;15:1123–1130
- . Follow-up of patients with Hodgkin’s disease following curative treatment (the routine CT scan is of little value) . Br J Cancer . 2003;89:482–486
- Early detection of relapse by whole-body positron emission tomography in the follow-up of patients with Hodgkin’s disease . Ann Oncol . 2003;14:123–130
- FDG-PET after two cycles of chemotherapy predicts treatment failure and progression-free survival in Hodgkin lymphoma . Blood . 2006;107:52–59
PII: S0147-0272(06)00017-1
doi: 10.1016/j.currproblcancer.2006.04.001
© 2006 Elsevier Inc. All rights reserved.
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Current Problems in Cancer
Volume 30, Issue 3
, Pages 107-158
, May 2006
