Current Problems in Cancer
Volume 29, Issue 6 , Pages 317-325 , November 2005

Handling Missing Data

  • Jefrey L. Huntington, BS
    • ,
  • Amylou Dueck, PhD

      Affiliations

    • Corresponding Author InformationAddress correspondence to Dr. Jeff A. Sloan, Mayo Clinic, Section of Biostatistics, Department of Health Science Research, 200 First St. S.W., Rochester, MN 55905, USA

References 

  1. Bernhard J , Cella DF , Coates AS , Fallowfield L , Ganz PA , Moinpour CM , et al.   Missing quality of life data in cancer clinical trials (serious problems and challenges) . Stat Med . 1998;17:517–532
  2. Wood AM , White IR , Thompson SG . Are missing outcome data adequately handled? A review of published randomized controlled trials in major medical journals . Clin Trials . 2004;1:368–376
  3. Fairclough D , Peterson HF , Chang V . Why are missing quality of life data a problem in clinical trials of cancer therapy? . Stat Med . 1998;17:667–677
  4. Magder LS . Simple approaches to assess the possible impact of missing outcome information on estimates of risk ratios, odds ratios, and risk differences . Cont Clin Trials . 2003;24:411–421
  5. Bernhard J , Peterson HF , Coates AS , Gusset H , Isley M , Hinkle R , et al.   Quality of life assessment in International Breast Cancer Study Group (IBCSG) trials (practical issues and factors associated with missing data) . Stat Med . 1998;17:587–601
  6. Vickers AJ , McCarney R . Use of a single global assessment to reduce missing data in a clinical trial with follow-up at one year . Control Clin Trials . 2003;24:731–735
  7. Fairclough D , Peterson H , Cella D , Bonomi P . Comparison of several model-based methods for analyzing incomplete quality of life data in cancer clinical trials . Stat Med . 1998;17:781–796
  8. Troxel AB , Fairclough DL , Curran D , Hahn EA . Statistical analysis of quality of life with missing data in cancer clinical trials . Stat Med . 1998;17:653–666
  9. Sprangers MAG , Moinpour CM , Moynihan TJ , Patrick DL , Revicki DA  and the Clinical Significance Consensus Group . Assessing meaningful changes in quality of life over time (a user’s guide for clinicians) . Mayo Clin Proc . 2002;77:561–571
  10. Simes RJ , Greatorex V , Gebski VJ . Practical approaches to minimize problems with missing quality of life data . Stat Med . 1998;17:725–737
  11. Sloan JA , Dueck A . Issues for statisticians in conducting analyses and translating results for quality of life end points in clinical trials . J Biopharm Stat . 2004;14:73–96
  12. Revicki DA , Swartz C , Gold K , Kallich J , Woolley M . Imputing health status scores missing due to morality (comparison of multiple techniques) . Qual Life Res . 1997;6:708
  13. McCorkle R , Young K . Development of a symptom distress scale . Cancer Nurs . 1978;1:373–378
  14. Loprinzi CL , Kugler JW , Sloan JA , Mailliard JA , Krood JE , Wilwerding MB , et al.   Randomized comparison of megestrol acetate versus dexamethasone verses fluoxymesterone for the treatment of cancer anorexia/cachexia . J Clin Oncol . 1999;17:3299–3306
  15. McGinnis W , Loprinzi CL , Buskirk S , Sloan JA , Drummond R , Frank A , et al.   Placebo-controlled trial of sucralfate for inhibiting radiation-induced esophagitis . J Clin Oncol . 1997;15:1239–1243
  16. Sloan JA , Loprinzi CL , Kuross SA , Miser AW , O’Fallon JR , Mahoney MR , et al.   Randomized comparison of four tools measuring overall quality of life in patients with advanced cancer . J Clin Oncol . 1998;16:3662–3673

PII: S0147-0272(05)00060-7

doi: 10.1016/j.currproblcancer.2005.09.006

Current Problems in Cancer
Volume 29, Issue 6 , Pages 317-325 , November 2005

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